Therefore, providing sufficient oxygen in tumor area may be beneficial for radiation therapy. To study the potential role of such strategy for brain tumor treatment, we used focused ultrasound to treat brain tumor bearing animals before radiation therapy. As compared with non-ultrasound treatment ...
Due to the diffuse invasion and long-distance migration of glioma cells, tumor resection usually needs to be followed by chemotherapy and radiation to delay tumor recurrence. A major obstacle for chemotherapeutic agents to be effective in the CNS is the blood–brain barrier (BBB), which restricts...
Heimburger R 1985 Ultrasound augmentation of central nervous system tumor therapy Clinical Guthkelch A, Carter L, Cassady J, Hynynen K, Iacono R, Johnson P, et al. 1991 Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial Clinical Yu...
Bacteria-based tumor therapy has recently attracted wide attentions due to its unique capability in targeting tumors and preferentially colonizing the core area of the tumor. Various therapeutic genes are also harbored into these engineering bacteria to
4.1. Non-invasive and targeted MSC transplantation into the brain using FUS Many clinical trials focused on the treatment of CNS diseases using stem cells have been conducted; however, few have reported successful outcomes, despite preclinical studies for each disease model showing excellent therapeutic...
The blood brain barrier (BBB) is a major obstacle to the delivery of therapeutics to the brain. Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles a
Lozano, in Brain Mapping, 2015 Focused Ultrasound High-intensity focused ultrasound was developed in the 1940s and has most often been used as a treatment for benign and malignant tumors including pancreas, liver, prostate, and breast carcinomas, soft tissue sarcomas, and uterine fibroids (Napoli...
The PRF, one type of modulation on the ultrasound temporal wave, may lead to dynamic acoustic radiation force (ARF)64. In recent studies, the ARF were inferred as the most probable energy form that induced PRF-dependent behavioral responses26and the calcium signaling61. In the present study, ...
our findings provide important scientific principles for the optimal clinical use of the technology," says senior author Rakesh Jain, Ph.D., director of the Steele Labs for Tumor Biology and the Cook Professor of Radiation Oncology at Harvard Medical ...
Nazeri said tauopathies such as Alzheimer's disease are similar to brain tumors. "While brain tumor behavior and treatment response are dictated by the specific mutations they harbor, the tau protein shows great heterogeneity in the pattern of phosphorylation as well as other post-translational modif...