Department of Sleep Medicine, Guy’s and St. Thomas’ Hospital NHS Foundation Trust, London, United Kingdom; Institute of Psychiatry, King’s College London, London, United KingdomJohn Wiley & Sons, Ltd.EpilepsiaOsei-Lah AD, Casadei A, Richardson MP, Alarcon G. Focal read- ing epilepsy--...
We studied 866 adults with epilepsy (377 males, mean age ± SD = 33.82 ± 9.48 years) and 1,328 healthy controls (588 males, mean age ± SD = 30.74 ± 8.30 years) from 18 centres in the international Epilepsy Working Group of ENIGMA39. Our analyses focu...
We first asked if we could reliably detect local slow waves during wakefulness in a cohort of people with focal epilepsy (n = 17) undergoing intracranial EEG recordings, and then whether such slow waves had key features of sleep slow waves (Fig.1). We used a validated algorithm for sl...
Conflict of Interest Disclosures: Dr French reported receiving salary support from the Epilepsy Foundation and for consulting work and/or attending scientific advisory boards on behalf of the Epilepsy Study Consortium during the conduct of the study; New York University salary support from Aeonian/Aeovi...
Slow waves of neuronal activity are a fundamental component of sleep that are proposed to have homeostatic and restorative functions. Despite this, their interaction with pathology is unclear and there is only indirect evidence of their presence during w
Epilepsy is a neurological condition marked by epileptic seizures. Focal cortical dysplasia (FCD) is a leading cause of drug-resistant epilepsy. Surgical removal of FCD lesions is the most effective treatment, heavily dependent on ...
1.1. Epilepsy and cognitive impairments Childhood epilepsy is known to be associated with cognitive impairments [1,2] as well as unfavorable psychosocial long-term outcomes [3]. This observation also applies to some extent – depending on the severity of the epileptic syndrome – to the self-limi...
Anticonvulsants including carbamazepine, usually prescribed to control epilepsy, have occasionally helped individuals with dystonia. Botulinum toxin. Minute amounts of this familiar toxin can be injected into affected muscles to provide temporary relief of focal dystonias. First used to treat blepharospasm...
Focal cortical dysplasia (FCD) represents the most common cause of drug-resistant focal epilepsy in children and young adults [6,8,34]. Based on clinicopathological features, FCD can be classified into type 1 (FCD I), type 2 (FCD II) and type 3 (FCD III). The focal nature of FCD is...
Somatic mosaicism is a known cause of neurological disorders, including developmental brain malformations and epilepsy. Brain mosaicism is traditionally attributed to post-zygotic genetic alterations arising in fetal development. Here we describe post-zy