研究者发现来自运动小鼠的血清,而不是来自静息小鼠的血清,激活了自噬报告细胞中的IKK和JNK,以及典型的FN1 -整合素信号分子,如Src和FAK的磷酸化,依赖于ITGA5和ITGB1,支持运动诱导血清确实刺激了α5β1整合素介导的细胞信号。 图A:IT...
Fig6:FN1突变导致软骨细胞基因表达异常。 野生型和C518FFN1杂合子(Hetero)和纯合子(Homo)软骨微球中ACAN、ADAMTS-5、FN1、ITGA5、ITGB1、COL10A1、ALPL、RUNX2、ITGA3和ITGAV的−Ct值的Box图; 选择了COL1A1和COL2A1作为...
ITGA5: Integrin α5 ITGB1: Integrin β1 FAK: Focal adhesion kinase Erk: Extracellular signal-regulated kinase MAPK: Mitogen-activated protein kinase PI3K: Phosphoinositide 3-kinase EMT: Epithelial to mesenchymal transition GEO: Gene Expression Omnibus qRT-PCR: Quantitative real-time polyme...
sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. Protein NameFibronectin Fn Cold-Insoluble Globulin Cig Cleaved Into - Anastellin - Ugl-Y1 - Ugl-Y2 - Ugl-Y3 Database LinksReactome: R-HSA-114608 Reactome: R-HSA-1474228...
the search for candidate receptors for the new embryo specific FN1 isoform, RNA expression analysis identified 5 伪 integrin subunits (ITGA2B, ITGA3, ITGA5, ITGA8, ITGAV) and 2 尾 integrin subunits (ITGB1 and ITGB3) with a similar or overlapping RNA expression pattern as compared to FN...