In tandem, we describe important findings from these techniques, and suggest promising avenues for their future application. Given the broad importance of metabolism to health and disease, more widespread application of these methods holds the potential to accelerate biomedical progress. This is a ...
The high prevalence of obesity in black women has been hypothesized to contribute to higher rates of coronary heart disease and total mortality. Investigat... Stevens,J E,Keil,... - 《Archives of Internal Medicine》 被引量: 389发表: 1992年 Energy expenditure, sex, and endogenous fuel availab...
Thus, human data point to, at least to some extent, similar cellular changes in the laboratory following a local challenge and the clinical disease of hay fever.doi:info:doi/10.2500/105065890782018154Pipkorn, UlfAmerican Journal of Rhinology
metabolic pathway optimization through metabolic engineering, and development of sensitive methods for early detection of disease phenotypes. The challenges in13C-MFA that still need to be addressed are related to measuring transient fluxes in systems that are not at metabolic steady-state, that is, ...
Entamoeba histolyticais a protozoan parasite responsible for the development of amoebiasis in humans. This disease is a worldwide public health problem that causes over 100 000 deaths per year1. Indeed, a recent report estimates the prevalence ofE. histolyticainfection at 42% in Mexico, 41% in...
coli that cause severe gastro-intestinal infections in humans. As such it is an important model organism for human disease research. We previously sequenced the genome of C. rodentium strain ICC168 and found that it had many features in common with other bacterial pathogens that have recently ...
4. An inorganic element, such as calcium, iron, potassium, sodium, or zinc, that is essential to the nutrition of humans, animals, and plants. 5. An ore. 6. Chiefly British a. minerals Mineral water. b. A soft drink. adj. 1. Of or relating to minerals: a mineral deposit. 2. ...
LEC rats are an accepted model for Wilson disease, an inherited disorder of copper excretion in humans. In LEC rats as well as in Wilson patients, the copper transporting ATPase, ATP7B, is defective. This ATPase is primarily expressed in the liver and serves in copper secretion via the bile...
In mouse pancreatic cancer, this is accommodated by the downregulation of protein synthesis, one of this tissue’s major energy costs. We propose that, as solid tumours develop, cancer cells shed energetically expensive tissue-specific functions, enabling uncontrolled growth despite a limited ability ...
Patients with end stage renal disease on hemodialysis have an increased mortality risk compared to the general population, which indicates that current renal replacement therapy requires improvements that translate into better patients' outcomes. One of the unmet needs in hemodialysis is the adequate ...