The patient had sexual dysfunction for 18聽years since the exposure to fluoxetine [ time to reaction onset and outcome not clearly stated ]. Author comment: "The longest case we have in the series has had [post-SSRI sexual dysfunction] for 18 years since a relatively brief exposure to ...
Fluoxetine is well absorbed after oral administration, with mean peak plasma concentrations (Cmax) of 15 to 55 μg/L after a single oral dose of 30 or 40mg. Time to Cmax(tmax) is 6 to 8 hours; coadministration with food increases tmaxby 3 to 5 hours, but the extent of absorption and...
In 1 breastfed (extent not stated) infant aged 11 weeks whose mother was taking fluoxetine 20 mg daily, no adverse reactions were noted clinically at the time of the study.[6] A small study compared the reaction to pain in infants of depressed mothers who had taken an SSRI during pregnanc...
to be of clinical importance. SSRIs also effectively treat anxious depression, dysthymia and atypical depression. Fluoxetine may provide more rapid onset of therapeutic effect because it can be started at closer to its usual full therapeutic dosage than other SSRIs or older antidepressants. SSRIs, ...
(Shapira et al., 2004—see below). Of the 74 subjects overall, 15 subjects withdrew from the 8-week study, 44 were partial or nonresponders to fluoxetine, and 15 were full responders to fluoxetine. The research has shown a significant response over time in both OCD subjects with...
[69]. Time to discontinuation was longer in those taking olanzapine (7.1months) and quetiapine (9.9months) than in those taking risperidone (3.6months); discontinuation rates were 58% for quetiapine, 61% for olanzapine, and 84% for risperidone. There were no significant differences in reasons ...
Time to peak: 6-8 hr (serum) Distribution Protein bound: 95% Vd: 12-43 L/kg Metabolism Hepatic P450 enzyme CYP2D6 substrate Enzymes induced: CYP2C9 Enzymes inhibited: CYP2C19, CYP2D6, CYP3A4 Metabolites: Norfluoxetine Elimination Half-life: 4-6 days (chronic administration); 1-3 days ...
The swimming time (sec) during each session was recorded. Treatment. Fluoxetine was administered by intercalating into the perfusion line a preloaded section of tubing to produce a timed pulse of the drug. On days 2 and 3, all rats received a 40-min pulse of fluoxetine (1.0 mM in Ringer...
trials. The stated frequencies represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse reaction of the type listed. A reaction was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline ...
The NLR test was used to observe the effects of MTX/LCV and fluoxetine on spatial working memory. None of the treatment groups showed a significant difference in the exploration time of the two objects in the familiarisation trial (p > 0.05, Fig. 2a), indicating no preference for the ...