In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber ...
The most noteworthy finding of this study was that the tracer injected into the left parietal lobe reached the right mandibular and parotid lymph nodules earlier. This result indicates the existence of a different and unknown pathway in the brain that communicates with the lymph nodes. Moreover, ...
A protein in cerebrospinal fluid helps boost cells that maintain brain function. By Jude Coleman Twitter Facebook Email Scientists have been trying to unravel the mysteries of why memory diminishes with age for decades. Now they have discovered a possible remedy — cerebrospinal fluid from younger ...
Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through ...
Interstitial fluid transports nutrients and removes waste between the organs and tissues in our body. In the brain, interstitial fluid is thought to be composed of circulating cerebrospinal fluid, cellular waste and blood plasma, and past research has shown a link between interstitial fluid flow and...
Recent years' research has revealed a specific, neuroprotective erythropoietin (EPO) system in the central nervous system (CNS) that is upregulated by hypoxia. The presence and dynamics of EPO in the cerebrospinal fluid (CSF) of patients with subarachnoid haemorrhage (SAH) has not been investigated...
CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain interstitial fluid (ISF) and facilitating the clearance of interstitial solutes, such as amyloid beta, in a pathway that we have termed the "glymphatic...
aThe blood-brain barrier, which prevents bacteria and other foreign bodies from passing from the blood into the fluid surrounding the brain, developed more slowly in some children, Dr Liang wrote in the journal Psychiatry Research, and these individuals' brains might be more susceptible to inflammat...
In the new study, the researchers took small pieces of embryonic rat brain tissue and, using a thin platinum wire, deftly moved them onto culture plates made up of CSF from rats of different ages. They found that when brain stem cells bathe in CSF from young rats, they furiously divide....
Levels of PLCγ, a phospholipase C (PLC) isozyme, were significantly increased in the cytosol in the injured left cortex (LC) at 5, 30 and 120 min after brain injury. In the same site, although levels of membrane PLCγ did not alter at 5 and 30 min, they were found to be decrease...