目的:探讨巨噬细胞炎性蛋白1α(Macrophage inflammatory protein-1α,MIP-1α)和酪氨酸激酶受体3配体(Flt3ligand,Flt3l)基因佐剂联合应用增强人乳头瘤病毒16型(Human papillomavirus16,HPV16)E7DNA疫苗免疫效果的可能性.方法:构建真核表达质粒pcDNA3/MIP-1α,pcDNA3/Flt3l和pcDNA3/HPV16E7.C57BL/6小鼠随机分为8...
pBOOST4-mFLT3L-mGMCSF plasmid encodes the murine Fms-like tyrosine kinase 3 ligand (FLT3L) and granulocyte-macrophage colony-stimulating factor (GM-CSF). FLTL3L is a synergistic hematopoietic growth factor that mediates cell survival, cell proliferation, and differentiation of dendritic cells [1]...
DC来源于骨髓多能造血干细胞,其起源、分化途径见图1。造血干细胞分化为淋巴干细胞和髓样干细胞后,髓样干细胞在粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony stimulating factor,GM-CSF)的刺激下分化为髓样DC(myeloid DC,MDC)。单核细胞与MDC拥有相同...
macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells ...
Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of immunotherapy that redirect T cells to specifically target cancer. However, tumor antigen heterogeneity remains a key challeng
In situ vaccination is a promising strategy to convert the immunosuppressive tumor microenvironment into an immunostimulatory one with limited systemic exposure and side effect. However, sustained clinical benefits require long-term and multidimensional
DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103CD11b DCs and macrophage-colony stimulating factor (M-CSF)-dependent, ... JH Choi,C Cheong,D Dandamudi,... - 《Immunity》 被引量: 386发表: 2011年 Expression of FMS-like Tyrosine Kinase 3 Ligand by Oncolytic...
Results The addition of 2% autologous plasma to this cytokine combination enhanced expansion of total cell numbers (3.2 fold versus 1.9 fold; p < 0.01), colony-forming units granulocyte- macrophage (CFU-GM) (22.0 fold versus 8.1 fold, p < 0.01) and burst-forming units erythroid (BFU-E) (...
目的:探讨巨噬细胞炎性蛋白1α(Macrophage inflammatory protein-1α,MIP-1α)和酪氨酸激酶受体3配体(Flt3ligand,Flt3l)基因佐剂联合应用增强人乳头瘤病毒16型(Human papillomavirus16,HPV16)E7DNA疫苗免疫效果的可能性。 2) fms-like tyrosine kinase 3(Flt3)ligand(FL) ...
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells Cancer Cell, 26 (2014), pp. 623-637, 10.1016/j.ccell.2014.09.006 View PDFView articleView in ScopusGoogle Scholar 22 C.S. Garris, S.P. Arlauckas, R.H...