PrognosisFMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a molecular genetic alteration significantly affecting the clinical outcome in patients with acute myeloid leukemia (AML). FLT3-ITD mutations are characterized by variable mutant-to-wild allelic ratios (ARs) and sizes of ...
13-21: FLT3/ITD mutation positive of AML patients without abnormal chromosome. 22: Control. 结 果 染色体核型分析 对125例AML患者20个中期分裂相的所有细胞进行了染色体核型分析,结果显示46例患者存在有染色体异常,总检出率为36.8%,各亚型检出率分别为M0 57.14%、M1 55. 20、56%、M2 38.71%、M3 50.0%、...
deregulated MCL-1 expression is linked to activation of FLT3 needs to be determined, inhibition of overexpressed MCL-1 might be a promising therapeutic approach to sensitize residual blasts or leukemic stem cells to chemotherapy and to overcome the poor prognosis of FLT3-ITD-positive AML patients. ...
Key words AML; FLT3 gene; MRD; leukemia prognosis; PCR J Exp Hematol 2007; 15(4):705-708 急性髓系白血病(acute myeloid leukemia, AML)是发病率最高的一种造血系统恶性肿瘤,化疗方法的完善和造血干细胞移植技术的开展使AML的预后有了很大改善,但仍有不少患者复发。目前认为,微小残留病(MRD)是白血病治疗...
Background: Activating mutations of FMS-like tyrosine kinase 3 (FLT3) occur in 30% of patients (pts) with de novo AML and confer a worse prognosis. KW-2449 is an oral multi-kinase inhibitor highly potent against mutant FLT3 (IC 50 = 1–7... J Cortes,GJ Roboz,H Kantarjian,... - ...
There is lack of data with regard to FLT3 expression in FLT3-ITD positive pediatric AML patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian subcontinent. Amongst 64 consecutive pediatric AML patients, FLT3-ITD was present in 12 (19%) patients. All patients ...
目的总结索拉非尼治疗伴FLT3-ITD突变急性髓系白血病(AML)的疗效,探讨该亚型急性白血病的有效疗法。 方法回顾性分析2012年1月至2015年2月苏州大学附属第一医院以MICM分型(M、I、C、M分别代表细胞形态学、免疫学、细胞遗传学和分子遗传学)确诊的42例伴FLT3-ITD突变AML患者资料,其中32例为化疗后未缓解或复发,10例为...
theprognosis,the FLT3-ITD gene mutation in diagnostic and evaluative values for AML were performed. RESULTS:FLT3-ITD gene mutation was found in 42 cases of 207 AML patients,the positive rate was 20. 29 %. FLT3-ITD positive patientsshowed 3 bands. FLT3-ITD gene mutation in 42 patients with...
PositiveAcuteMyeloidLeukemiaPatients Abstract Objective:FLT3-ITDpositiveacutemyeloidleukemiahasbeenclassifiedashigh-risk groupwithpoorprognosis.FLT3-ITDmutationoccurredinvariousnumber,lengthand burden.TheaimofthisstudyistoanalyzetherelationshipbetweenFLT3-ITDmutation ...
Allogeneic Hematopoietic Stem Cell Transplantation in FLT3 -ITD–Positive Acute Myelogenous Leukemia: The Role for FLT3 Tyrosine Kinase Inhibitors Post-Tra... •With recent advances, allo-HSCT improves survival in patients with AML.•FLT3-ITD mutations are associated with poor prognosis, even after...