Breast cancerFlaxseed oilMCF-7 xenograftsFlaxseed (FS) has been shown to attenuate mammary tumorigenesis, possibly due to its high α-linolenic acid (ALA)-rich oil (FSO) content. This study determined the effect of FSO on the growth of estrogen receptor-positive human breast tumors (MCF-7) ...
Thus, FSO regressed estrogen receptor-positive human breast tumorigenesis at high E2 levels via downregulation of the growth factor mediated pathway, likely through its ALA content, and may explain the anti-tumorigenicity of FS. 展开 关键词: α-linolenic acid Athymic nude mice Breast cancer Flaxseed...
Because flaxseed contains phytoestrogenic lignans, patients with estrogen receptor– positive breast cancer should use caution before taking flaxseed supplements. For additional information, visit the Memorial Sloan-Kettering Cancer Center Integrative Medicine Service website, "About Herbs," at ...
Finally, IL-1Ra therapy of tumor-bearing mice opposed estrogen-dependent breast cancer growth and decreased angiogenesis. We conclude that the release of IL-1s both by cancer cells and the stroma, where macrophages are a key component, may offer feasible targets for antiestrogen therapy and ...
Regular consumption of flaxseed mayprotect the body from colon cancer, prostate cancer, and breast cancer. Omega-3 fatty acids prevent cancerous cells from latching onto healthy cells. If cancerous tumors attempt to form, the lignans contained in flaxseed stop the formation of new blood supply (...
Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells Although tamoxifen (TAM) is used for the front-line treatment and prevention of estrogen receptor-positive (ER+) breast tumors, nearly 40% of estrogen-depe...
Briefly, KG-1 cells were incubated with the cell-permeant 20,70-dichlorodihydrofluorescein diacetate (H2DCFDA), and then treated with increasing concentrations of ENL. Positive control cells were incubated with the ROS inducer Tert-Butyl Hydrogen Peroxide (TBHP) at a concentration of 75 μM. ...
Here, we investigated the in vitro effects of flaxseed sprouts on cell growth and apoptosis of human breast cancer cells. In a series of in vitro experiments, estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) cells were cultured and treated with flaxseed sprouts, ...
Verheus M, Gils CHV, Keinan-Boker L, Grace PB, Bingham SA, Peeters PHM (2007) Plasma phytoestrogens and subsequent breast cancer risk. J Clin Oncol 25:648–655 Article CAS Google Scholar Brzezinsk A, Debi A (1999) Phytoestrogens: The “natural” selective estrogen receptor modulators? Eur...
Lignans, which have plant estrogen as well as antioxidant properties, are beneficial to maintaining hormonal equilibrium. It has been estimated that flaxseed contains between 75 and 800 times the amount of lignans that are found in other plant foods. ...