The Arabidopsis Flavin-Dependent Monooxygenase FMO1 Is an Essential Component of Biologically Induced Systemic Acquired Resistance1[OA]Upon localized attack by necrotizing pathogens, plants gradually develop increased resistance against subsequent infections at the whole-plant level, a phenomenon known as ...
bifunctional cytochrome P450 enzyme HpCYP81AA1-catalyzed formation of 1,3,7-trithydroxyxanthone in the plantHypericum calycinum16, multiple enzymes-mediated oxidative transformation of chrysophanol into the xanthone blennolide A in fungi17, and a single flavoprotein monooxygenase (FPMO18) XanO4-cataly...
Plutella xylostella Flavin monooxygenase Resistance Chlorantraniliprole Diamide Insecticides 1. Introduction The diamondback moth, Plutella xylostella, is one of the most destructive insect pests of cruciferous crops worldwide resulting in estimated costs to the global economy of US$4–5 billion per annum...
Nevertheless, a low substrate pKa was found to correlate with rapid hydroxylation by HadA (a dehalogenating monooxygenase), implying that substrate deprotonation is a rate-contributing step (35). Similarly, the phenolic pKa of substrate bound to C2 may be unusually low (Fig. 1) because the ...
et al. Identification of a hotspot residue for improving the thermostability of a flavin-dependent monooxygenase. ChemBioChem 20, 3020–3031 (2019). Article CAS PubMed Google Scholar Download references Acknowledgements We thank the Thailand Science Research Innovation and NSRF via the Program ...
Coq6p is a peripheral membrane protein that localizes to the matrix side of the inner mitochondrial membrane. Based on sequence homology to known proteins, we suggest that COQ6 encodes a flavin-dependent monooxygenase required for one or more steps in Q biosynthesis. 展开 ...
The selenazole ring-opened metabolites of ebselen, 2-selenylbenzanilide and 2-(methylseleno)benzanilide, are substrates for flavin-containing monooxygenase from pig liver. The Km values were 25 and 3 microM, respectively, measured at 37 degrees C, pH 7.4, in the presence of 1 mM GSH. Th...
Xanthone-containing natural products display diverse pharmacological properties. The biosynthetic mechanisms of the xanthone formation have not been well documented. Here we show that the flavoprotein monooxygenase FlsO1 in the biosynthesis of fluostatins not only functionally compensates for the ...
Comparative genomic analysis revealed that the gene cluster containing sulfonamide monooxygenase (renamed as sulX) and flavin reductase (sulR) was highly conserved in a genomic island shared among sulfonamide-degrading actinobacteria, all of which also contained sul1-carrying class 1 integrons. These ...
Three different enzyme families are known to produce oxime moieties: (1) cytochrome P450–dependent monooxygenases, (2) ferritin-like enzymes, and (3) flavin-dependent N-monooxygenases. Glucosinolates are usually made via a pathway involving a cytochrome P450–dependent monooxygenase that catalyzes succe...