侧翼区(flanking region) 根据维基定义:The 5' flanking region is a region of DNA that is adjacent to the 5' end of the gene. The 5' flanking region contains the promoter, and may contain enhancers or other protein binding sites. It is the region of DNA that is not transcribed into RNA....
multigene family involves the recognition of various regulatory sequences ( cis -acting elements) that specify the distinct tissue type and developmental program of expression for each actin paralogue, which implies that the distribution of cis -acting elements may be unique for each paralogue gene. ...
flanking sequences analyzed, and it is assumed, that the presence of this element determines gene expression in the lactating mammary gland, and binding sites for general activator and represser factors, surrounding the milk protein gene specific element, are important for regulation of gene activ...
Fibrinogen is coded by three separate genes located in a 50kb region of chromosome 4 and organized in a α - β - γ orientation with an inversion of the gene 3- A human genomic library was constructed using the EMBL4 phage and screened with cDNA probes coding for human fibrinogen Aα, ...
RNA blot hybridization analysis indicated that developmental changes of the isozymes in brain and skeletal muscle were regulated at the level of RNA splicing. The 5'-flanking region of the gene has no "TATA box" or "CAAT box," but contains potential Sp1 binding sites. Bacterial chloramphenicol ...
Thus, these sequences may serve only a spacing function, and the T.Ag-binding sites appear not to be necessary for expression. However, coexpression of T.Ag markedly reduced expression of a U1 gene containing a high-affinity T.Ag-binding site (from the SV40 genome) in place of the U1 ...
Thus, these sequences may serve only a spacing function, and the T·Ag-binding sites appear not to be necessary for expression. However, coexpression of T·Ag markedly reduced expression of a U1 gene containing a high-affinity T·Ag-binding site (from the SV40 genome) in place of the ...
Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Methylation Hot Spots in the 5′ Flanking Region Denote Silencing of the O6-Methylguanine-DNA Methyltransferase Gene Point mutations define a sequence flanking the AUG initiator codon that modulates transla...
1B) is designated nucleotide +1 of the gene (large arrow). The minor transcription start site is indicated with an asterisk. Putative transcription factor-binding sites (TFSEARCH score > 85) are shown as boxes. (B) Primer extension analysis of the human HELB transcripts. Total RNAs (10...
In a single isolate we found one to seven sites.We observed that the amount of PbGP43 transcripts accumulated in P. brasiliensis Pb339 grown in defined medium was about 1,000-fold higher than in Pb18 and 120-fold higher than in Pb3. We have described a series of features in the gene...