Several sequence motifs were identified in the 5' promoter region which could be responsible for the regulation of synthesis of this gene. Multiple transcription initiation sites were identified by S1 nuclease mapping.doi:10.1111/j.1432-1033.1987.tb13300.xInes NOWAK...
Noncoding region upstream (5′ flanking) or downstream (3′ flanking) of a gene. Acis-regulatory element for gene expression is often found in the 5′ flanking region. Adapter protein Contains multiple docking sites for other proteins but lacksenzymatic activity; functions as an “adapter” by ...
侧翼区(flanking region) 根据维基定义:The 5' flanking region is a region of DNA that is adjacent to the 5' end of the gene. The 5' flanking region contains the promoter, and may contain enhancers or other protein binding sites. It is the region of DNA that is not transcribed into RNA....
In this region additional binding sites for potential transcription factors were found that are identical to known regulatory sequences. The possible roles of these putative regulatory elements in the interleukin-2 gene regulation remain to be proven. The 5′ end of the sequence contains almost full...
1B) is designated nucleotide +1 of the gene (large arrow). The minor transcription start site is indicated with an asterisk. Putative transcription factor-binding sites (TFSEARCH score > 85) are shown as boxes. (B) Primer extension analysis of the human HELB transcripts. Total RNAs (10...
Butta N, Gonzalez-Manchon C, Arias-Salgado EG, Ayuso MS, Parrilla R (2001) Cloning and functional characterization of the 5′ flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2. Eur J Biochem 268:3017–3027...
Transcriptional regulation of gene expression is enacted mainly through binding of transcription factors (TFs) to specific, short DNA sites in cis-regulatory regions of genes. Most TFs are members of protein families that share a common DNA-binding domain and thus recognize similar DNA-binding ...
In a single isolate we found one to seven sites.We observed that the amount of PbGP43 transcripts accumulated in P. brasiliensis Pb339 grown in defined medium was about 1,000-fold higher than in Pb18 and 120-fold higher than in Pb3. We have described a series of features in the gene...
The major transcription start site determined by primer extension analysis (Fig. 1B) is designated nucleotide + 1 of the gene (large arrow). The minor transcription start site is indicated with an asterisk. Putative transcription factor-binding sites (TFSEARCH score > 85) are shown...
The putative promoter region of the gene contained no obvious TATA or CCAAT element in the expected positions, but multiple putative binding sites for transcriptional factors, such as Sp1, AP-1, AP-2, AP-3, EGR-1, EGR-2, NF-κB and HIP1, were detected. We found the existence of a...