Potential for improved therapeutic index of FK506 in liposomal formulation demonstrated in a mouse cardiac allograft model. Transplantation 1999; 67: 1205–8Moffatt, S. D., McAlister, V., Calne, R. Y., and Metcalfe, S. M. (1999) Potential for improved therapeutic index of FK506 in ...
Another Cn inhibitor, cyclosporine A (CsA) showed similar effects on anabolic and catabolic activity of OA chondrocytes and reduced cartilage damage in a collagenase induced OA mouse model13. However, this study only measured macroscopical and microscopical cartilage damage ex vivo and did not ...
and highlights a novel key function for PI P28 isomerization during PI folding. As such, our findings create an opportunity to investigate the potential of PI P28 isomerization status as a biomarker of early diabetes as well as a potential novel therapeutic target capable of improving PI folding....
Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration. Sci. Rep. 2015, 5, 10535. [CrossRef] [PubMed] 76. De Luigi, A.; Colombo, L.; Diomede, L.; Capobianco, R.; Mangieri, M.; Miccolo, C.; Limido, L.; Forloni, G.; ...