using Adamax as the optimizer and a slanted triangular learning rate. We applied dropout on the hidden state outputs of BERT to avoid overfitting. Hyperparameters were optimized using SigOpt (https://app.sigopt.com/docs/intro/overview). We employed threefold nested cross-validation (outer loop is...
Log2(TPM+1) values were plotted as a violin plot generated using the Seaborn package in Python (Figure 4). Differences between proximal 5TRa and proximal non-5TRa were assessed using logistic regression. Vista enhancer validation of distal ≥3TRa peaks To determine whether ≥3TRa peaks are ...
Finally, the solution structure of L1MK-Ctd was determined by NMR.13C-edited and15N-edited NOESY-HSQC experiments were carried out on uniformly13C,15N-labeled L1MK-Ctd. The NOESY cross-peaks in the spectra provided both the intra-protomer connectivities and the inter-protomer connectivities. E...