Strong positive expression of ALK protein can be interpreted as EML4-ALK gene rearrangement.%目的:探讨棘皮类微管蛋白4(echinoderm microtubule-associated protein-like 4, EML4)与间变性淋巴瘤激酶基因(ana-plastic lymphoma kinase, ALK)融合在肺鳞状细胞癌中的发生率,为进一步开展靶向治疗提供...
Purpose To investigate the occurrence of echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplas-tic lymphoma kinase (ALK) gene rearrangements in lung squamous cell carcinomas (SCC), and to provide with a test for targeted therapy of SCC. Methods In this study, we analyzed...
Introduction: The Italian Association of Medical Oncology and the Italian Society of Anatomic Pathology and Diagnostic Cytopathology organized an external quality assessment (EQA) scheme for anaplastic lymphoma kinase (ALK) rearrangement by florescence in situ hybrid- ization (FISH) analysis in non-small...
plasticlymphomakinase,ALK)融合在肺鳞状细胞癌中的发生率,为进一步开展靶向治疗提供参考。方法 采用高度特异性和 敏感性的ALK抗体(D5F3)对219例肺鳞状细胞癌石蜡包埋组织标本进行免疫组化染色,并对阳性标本行EML4ALK荧光原 位杂交技术(fluorescenceinsituhybridization,FISH)检测。结果 免疫组化染色检出ALK强阳性标本4例...
Lymphoma(probesordered individuallyastestcode2002298) Burkitt8q24MYC Diffuselargecell3q27BCL6 Folliculart(14;18)(q32;q21)IGH-BCL2 IgHrearrangement14q32IGH Mantlecellt(11;14)(q13;q32)IGH-CCND1 MALT18q21MALT1 Toorderindividualprobes,useARUPtestcode2002298,Chromosome,FISHInterphase,andspecifythedesire...
The fluorescence in situ hybridization (FISH) technique for detection of the 9;22 translocation was compared with the gold standard of conventional cytogen... M Nolte,M Werner,M Ewig,... - 《Leukemia & Lymphoma》 被引量: 135发表: 1996年 Fluorescence In Situ Hybridization (FISH) - Application...
The related cancers T-lymphoblastic lymphoma (T-LBL) and acute T-lymphoblastic leukemia (T-ALL) are intriguing examples because despite their genetic similarity, T-LBL develops as a localized disease in some patients, whereas in others the disease progresses to T-ALL and spreads rapidly. 展开 ...
Results from the FISH protocol tests indicated that sperm produced during the Hodgkin lymphoma treatment had 10 times more chromosomal defects compared with sperm produced prior to treatment. But by month six post-treatment, the patients’ sperm had returned to pre-treatment quality. “We are excite...
Anaplastic Lymphoma Kinase Testing: IHC vs. FISH vs. NGS[J]. Current treatment options in oncology, 2017, 18(12): 71. Quijada-Álamo M.; et al. Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in ...
原发性胃肠淋巴瘤(primarygastrointestinallymphoma,PGIL)是最 常见的结外淋巴瘤,临床表现无特异性,病理分类复杂,早期诊断比 较困难,极易误诊和漏诊。基因诊断已逐渐成为淋巴瘤的重要诊断手 段,基因异常在结性淋巴瘤的发生、发展、预后等方面均有重要意义。