In the KEYNOTE-859 and ORIENT-16 trials, pembrolizumab or sintilimab combined with chemotherapy yielded a median OS of 12.9 and 15.2 months, respectively.3,7,27,28 In contrast, this study showed substantial clinical benefits. Therefore, the integration of apatinib with camrelizumab and ...
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We first validated our transmission model by comparing simulations with data from a long-term trial in Tororo, Uganda, in which children aged 4 months–1 year were randomized to receive AL or DHA–PQP every time they presented with malaria at health facilities and were followed up until age o...
“Old Dominion’s financial results improved during the first quarter despite continued softness in the domestic economy. For the second straight quarter, both our revenue and earnings per diluted share increased on a year-over-year basis. We achieved these results by continuing ...
Incorporating these measures in future studies would provide a more comprehensive assessment of the benefits and risks of nivolumab plus chemotherapy in this patient population. 5. Conclusions In conclusion, this real-world study demonstrates the efficacy and safety of nivolumab in combination with ...
p< 0.001). In contrast, no significant difference was observed among the <1% PD-L1 expression subgroup (p= 0.883). The median PFS-2 (the time from first-line treatment to progression to the second-line treatment or death) in the SEQ group was significantly longer than the median PFS in...
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Despite these benefits, our results showed that osimertinib could not be regarded as cost-effective compared to all other TKIs. Therefore, it is of great importance to negotiate a lower price for osimertinib. Conclusion This study showed that the cost-effectiveness of afatinib compared to erlotinib...
Catheter ablation has emerged as the most effective long-term rhythm controlling strategy in patients with symptomatic atrial fibrillation (AF). Over the last few years, the role of ablation has shifted from a last-resort strategy toward a first-line approach in AF management. The purpose of thi...
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