First-in-human clinical trial design of a first-in-class theranostic approach with a peptide-based radioligand targeting CA IX-expressing tumors.283-237-255,283-424-3231-2482,613-545,283-237-267-6887-6888,613-225-325,613-225-2782,261-137-7318,6,5,4,3,3,3,3,38092-19568,1...
First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurementsMelanoma is an aggressive skin cancer that originates from melanocytes and, especially in the case of early-stage melanoma, is distributed adjacent to the epidermis and superficial dermis....
植入物设计为以 10mL/h 的压力梯度排出≤8 毫米汞柱。发起人发起(CereVasc Inc.,Auburndale,马萨诸塞州,美国)和支持的、前瞻性、单中心、开放标签、单臂试点研究已启动(ClinicalTrials.Gov NCT04758611),以评估使用 eShunt 的交流性脑积水治疗。 案例介绍 一位八十多岁的患者因大脑中动脉动脉瘤破裂而出现蛛网膜...
3 FDA (2005) stimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers, US Department of Health and Human Services FDA, Center for Drug Evaluation and Research, Silver Spring, MD.4 EMEA (2017) Guideline on strategies to identify and ...
even for those with similar physico-chemical characteristics or identical pharmacological mechanisms of action. So, PK analysis may be planned, performed and interpreted by various methods in different FIH studies, which should be justified by the properties of the drug and...
First-in-Human Clinical Application of the Medyria TrackCath System in Endovascular Repair of Complex Aortic Aneurysms (ACCESS Trial): A Prospective Multicenter Single-Arm Clinical Trial: 来自 科研支点 喜欢 0 阅读量: 26 摘要: The Medyria TrackCath Catheter (MedTCC) is an innovative, thermal ...
Clinical and angiographic results with the next- generation resolute stent system: a prospective, multicenter, first- in-human trial. JACC Cardiovasc Interv 2009;2:977-85.Meredith IT, Worthley S, Whitbourn R, et al. Clinical and angiographic results with the next‐generation Resolute stent system...
BEIJING, Dec. 29 (Xinhua) -- Chinese researchers have completed the First-in-Man (FIM) clinical trial using a single-arm laparoscopic surgical robot in China, according to the Beijing Friendship Hospital affiliated to Capital Medical University. ...
Currently, ERY974, a humanized IgG4 bispecific T cell-redirecting antibody recognizing glypican-3 and CD3, is in phase I clinical trials. After a first-in-human clinical trial of an anti-CD28 agonist monoclonal antibody resulting in severe life-threatening adverse events, the minimal anticipated ...
Dose selection for first-in-human (FIH) clinical trials with monoclonal antibodies (mAbs) is based on specifically designed preclinical pharmacology and to... Patrick,Y,Muller,... - 《Current Opinion in Biotechnology》 被引量: 60发表: 2009年 Risks and Benefits of Phase I Clinical Trials Evalua...