Fipronil(Fig. 77-4) is anN-phenylpyrazole, which competitively antagonizes the β subunit of the GABAα receptor. The binding to insect GABA is 1000-fold greater than that in human brain,61likely accounting for the low toxicity in humans. ...
Fipronil elicits neurotoxicity in mammals by inhibition of GABAA-gated chloride channels, producing hyperexcitability of the central nervous system. Overdosage due to accidental ingestion often leads to serious toxicosis. There is no specific antidote for the toxicity of fipronil. The manufacturer warns ...
ToxicityLD50 in rats (mg/kg): 100 orally; >2000 dermally (Colliot); in mice (mg/kg): 32 i.p. (Cole) NFPA 704 0 40 Fipronil priceMore Price(29) ManufacturerProduct numberProduct descriptionCAS numberPackagingPriceUpdatedBuy Sigma-Aldrich46451Fipronil PESTANAL120068-37-3100mg$2512024-03-01Bu...
Toxicity: Acute oral LD50 for male rats is 1680 mg/kg ,for female is 1575 mg/kg. Acute percutaneous LD50 is more than 2000kg/kg. Application: 1.Fipronil is used for controlling of multiple species of thrips on a broad range of crops by foliar, soil or seed treatment;2.Co...
catsdogsThe mode of action of fipronil is described, with reference to its insecticidal and acaricidal activity. Its much greater toxicity for invertebrates is highlighted, and it is noted that it is very effective against invertebrates that have developed resistance to dieldrin, even though they ...
resulting in the central nervous system of insects and ticks disorder until death.Mainly through thestomach toxicity andcontact toxicity to kill , but also has a certain role in drug action. Veterinary clinical use is mainly used to drive ...
Synergistic antioxidant effects of resveratrol and curcumin against fipronil-triggered oxidative damage in male albino rats Fipronil (FPN), a phenylpyrazole insecticide, has been receiving increased attention owing to its toxicity, which is largely mediated through its effects o... G Albasher,MA Daim,...
Toxicity of High and Low Highly Toxic and High Toxic Drugs Mode Systemic Insecticide Toxicological Effect Nerve Poison Product Name Fipronil CAS 120068-37-3 Molecular Weight 437.148 Molecular Formula C12h4cl2f6n4OS Density 1.9±0.1 g/cm3 Assay HPLC99% Sample 10g Available Factory ...
Poisoned dogs and cats usually show signs of tremors, convulsions, seizures, and death. Following dermal exposure, fipronil toxicity is more pronounced in rabbits than in rats and mice. Humans exposed to fipronil by ingestion may show symptoms of headache, tonic-clonic convulsions, seizures, par...
Toxicity and Risk Factors. Fipronil has a wide safety margin. Fipronil has no known interactions with commonly used biologics, pharmaceuticals, or ectoparasites.5 In dermal toxicity studies, the application of a 0.29% spray to dogs and cats at a dose five times higher than the recommended dose...