FIP-fve為一個從針菇 (Flammulina velutipes) 純化出的免疫調節蛋白,被歸在真菌免疫調節蛋白 (FIPs),此的蛋白具有調控 IFN-γ 增加,減少過敏發炎,而對抗癌症功效的文獻較少.Rac1是一個小分子訊息傳遞 G 蛋白,與許多細胞的訊息調控,如細胞增生,細胞間的附著與細胞的移調控等.RACGAP1 (Rac GTP水解酶活化蛋白...
Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture Expression of FIP-fve gene in E.coli and preliminary study on its activity
We found that FIP-gts exhibited better immunomodulatory activity than FIP-fve. Activities were both greatly reduced with duration of heating. For digestibility, FIP-fve was more resistant than FIP-gts to digestive enzymes in simulated gastric fluid and simulated intestinal fluid. IFN- production is...
郑中军目前担任青岛盛锦添防水工程有限公司法定代表人,同时担任青岛盛锦添防水工程有限公司执行董事兼总经理;二、郑中军投资情况:郑中军目前是青岛盛锦添防水工程有限公司直接控股股东,持股比例为100%;目前郑中军投资青岛盛锦添防水工程有限公司最终收益股份为100%;三、郑中军的商业合作伙伴:基于公开数据展示,郑中军与...
FIP-fve 為純化自金針菇之免疫調節蛋白,研究指出 FIP-fve 可刺激人類周邊血淋巴細胞增生及分泌 IFN-γ,並使免疫反應趨向於 TH1 反應;體內試驗亦發現,口服 FIP-fve 可降低小鼠食物過敏的症狀,延長罹癌小鼠之壽命及抑制腫瘤大小.生物可及性 (bioaccessibility) 是指活性成分自食物基質釋出後,可通過腸胃道的部分,...
The results of this study suggest that FIP-fve suppresses asthma, inflammation, and respiratory pathogenesis stimulated by Der m. FIP-fve is able to maintain immunomodulatory activity even in simulated gastric fluid and intestinal fluid. FIP-fve could be a safe and stable agent for suppression ...
FIP-fveRespiratory syncytial virusInflammatoryNF-κBAntiviral agentRespiratory syncytial virus (RSV) causes bronchiolitis in children followed by inflammation and asthma-like symptoms. The development of preventive therapy for this virus continues to pose a challenge. Fungal immunomodulatory proteins (FIPs) ...
Functional expression of FIP-fve, a fungal immunomodulatory protein from the edible mushroom Flammulina velutipes in Pichia pastoris GS115. Lin J W,Jia J,Shen Y H, et al. Journal of Biotechnology . 2013LIN J W, JIA J, SHEN Y H, et al. Functional expression of FIP-fve, a fungal ...
DERMATOPHAGOIDESLABORATORY miceASTHMA risk factorsHOUSE dust mitesThe article discusses research investigating the role of fungal immunomodulatory protein (FIP-fve) isolated from Flammulina velutipes in alleviation of asthma and inflammation induced from house dust mite (HDM) Dermat...
(1%,V/V)为碳源进行诱导型表达4d达到最高,粗蛋白表达量为158.2 mg/L,在以葡萄糖(10%)和甘油(1%,V/V)为碳源进行组成型分别在表达第4天和第5天达到最高,粗蛋白分别为46.3 mg/L和29.5 mg/L.SDS-PAGE及Western blotting证明重组Fip-fve已正确表达,血细胞凝集活性检测初步证明重组Fip-fve具有良好生物...