Protein sequence motifs are patterns of residues with different structural and/or functional features. They were recognized with protein multiple sequence/structural alignment methods as typical conserved signatures of protein families [1]. The general term “protein motif” includes different types of sig...
Notationis the set of polynomials of degree at most, andis the set of rational functions of type at most. Unless mentioned otherwise,fis assumed to be meromorphic in a regionin the complex plane, anddenotes the type of the rational approximantthat our algorithm finds:, that is,and. When ne...
Classification of structures is necessary to organize the structural data and to derive constraints that determine the range of possible protein folds. Comparing domains with the same fold that are homologous with those that are thought to be analogous provides insight into which residues are critical...
methylates lysine-27 and lysine-9 residues of histone h3. figure 5 conserved complexes between human (a) and mouse (b) predicted by our pipeline. figure 5 shows a pair of complexes conserved between human (a) and mouse (b) predicted by our pipeline. full size image table 6 top-5 go ...
1 In response to extracellular inducers, IκBα is first phosphorylated on the N-terminal two serine (S) residues, S32 and S36, by IKK kinase complex composed of two catalytic subunits, IKKα and IKKβ, and one regulatory subunit, NEMO (IKKγ). This phosphorylation leads to the conjugation...
Examples of newly found modifications include +12.000 Da (+C atom) incorporation into proline residues of peptides from proline-rich proteins found in human saliva. This modification is hypothesized to increase the known activity of the peptide....
Thus, one of the key functions of the viral MP is to enlarge PD to allow passage of some form of the virus into the adjacent cell (Wolf et al., 1989). The MP also plays an active, if less defined, role in the physical movement of the virus across the PD. Plant virus MPs can ...
Consequently, 21 residues from both sites and phases were analysed by GC-MS in SIM mode to check for the presence of aquatic or freshwater biomarkers, which would denote the processing of shellfish/crustaceans, fish and marine mammals. These comprise long-chain ω-(o-alkylphenyl) alkanoic ...
Irrespective of the exact MEMO1 residues involved, MEMO1 clearly interacts with activated and thus phosphorylated, ERBB2 at the Y1227 residue. As an adapter molecule, MEMO1 was shown to link ERBB2 signaling to cell migration events (discussed in more detail below) [1]. For example, MEMO1 ...