The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin, SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved, they have been recognized for their signaling engagements and trafficking abilities, navigating a number of molecules ...
Rga4, one of the nine RhoGAPs present in the fission yeast, is a key factor in the control of cell polarity and morphogenesis by negatively regulating the activity of the essential Rho GTPase Cdc42. We have demonstrated that Rga4 is also a GAP for Rho2 GTPase, which acts upstream of ...
production of mmps in human cerebral endothelial cells and their role in shedding adhesion molecules. j neuropathol exp neurol 60:320–327.https://doi.org/10.1093/jnen/60.4.320 hur jy, teranishi y, kihara t et al (2012) identification of novel γ-secretase-associated proteins in detergent-...
polarity in the epithelial cells by the Hippo pathway [51], its primary inhibitor, mainly by phosphorylation and proteasomal degradation, preventing nuclear entry. Once in the nucleus, YAP binds to members of the TEAD (Transcriptional Enhanced Associate Domain) transcription factors that possess a DNA...