Filorexant (MK-6096) 是一种口服有效且选择性可逆的 OX1 和 OX2 受体拮抗剂,Ki 值小于3nM。 Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM). AI解读 产品属性 关联靶点(人) 关联靶点(其它种属) 作用机制 名称...
MK-6096orexinmigraineprophylaxisBackground This study explored whether antagonismChabi, A.Zhang, Y.Jackson, S.Cady, R.Lines, C.Herring, W.J.Connor, K.M.Michelson, D.CEPHALALGIAChabi A, Zhang Y, Jackson S, Cady R, Lines C et al. Ran- domized controlled trial of the orexin receptor ...
FilorexantMK-6096orexinmigraineprophylaxisBackground This study explored whether antagonism of orexin receptors might be an effective mechanism for migraine prevention.doi:10.1177/0333102414544979Almira ChabiYing ZhangSaheeda JacksonRoger CadyChristopher LinesW Joseph Herring...