Lu, J, Le, Y (1998) Ficolins and the fibrinogen-like domain. Immunobiology 199: pp. 190-199Lu J, Le Y (1998) Ficolins and the fibrinogen-like domain. Immunobiology 199(2):190–199Lu, J. and Y. Le (1998). "Ficolins and the fibrinogen-like domain." Immunobiology Lu, J., P. ...
Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and manno...
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modu
Ficolins contain both a collagen-like domain and a fibrinogen-like domain that has a specific binding affinity for N-acetylglucosamine. They can act as opsonins and complex with MASPs to activate the complement pathway [14]. Three types of human ficolin are known to date: L-ficolin (ficolin...
(1998). Ficolins and the fibrinogen-like domain. Immunobiology, Vol. 199, No. 2, pp. 190-199.Lu, J. and Y. Le. 1998. Ficolins and the fibrinogen-like domain. Immunobiology 199: 190-199.J. Lu and Y. Le, "Ficolins and the fibrinogen-like domain," Immunobiology, vol. 199, no....
L-ficolin is a serum lectin synthesized (as a ~37 kDa polypeptide) predominantly by the liver, and is one of the key molecules of the innate immune system. It has an amino (N)-terminal cysteine-rich region, a middle stretch of a collagen-like sequence, and a fibrinogen-like domain in...
Each subunit is composed of an N-terminal region including two cysteine residues, a collagen-like domain, a neck region and a fibrinogen-like domain. Electron microscopy of the whole proteins of human ficolin-2 and ficolin-3 show bouquet-like images, similar to those first described for C1q....
Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc)....
fibrinogen-like domaininnate immunityN-acetyl groupX-ray crystallographyInnate immunity relies critically upon the ability of a few pattern recognition molecules to sense molecular markers on pathogens, but little is known about these interactions at the atomic level. Human L-and H-ficolins are ...
AbstractFicolins, a kind of lectin containing collagen-like and fibrinogen-related domains (FReDs, also known as FBG or FREP), are involved in the first line of host defense against pathogens. In this study, two ficolins, namely, MrFico1 and MrFico2, from the giant freshwater prawn ...