1399 Figure 2 Tissue microarray slide stained for hypoxia-inducible factor-1a (HIF-1a), carbonic anhydrase IX (CAIX) and glucose transporter-1 (Glut-1), all scored positive in the same case of male breast cancer. Modern Pathology (2012) 25, 1397–1404 1400 Hypoxia in male breast cancer ...
Fibrotic Phenotype of Peritumour Mesenteric Adipose Tissue in Human Colon Cancer: A Potential Hallmark of Metastatic Properties The impact of tumour associated stroma on cancer metastasis is an emerging field. However, cancer associated genes in peritumoral adipose tissue (pAT) in h... M Tabuso,...
lung disease (ILD). ILD affects the lung in three ways: first, the tissue is damaged in some known or unknown way; second, the walls of the air sacs become inflamed; and third, scarring (or fibrosis) begins in the interstitium (tissue between the air sacs), and the lung becomes ...
In breast cancer specifically, piperine not only enhances curcumin absorption but also exhibits its own anticancer properties to inhibit breast cancer cell proliferation by inducing cell cycle arrest and apoptosis. The combination of curcumin and piperine has shown promise in preclinical studies, ...
contamination. All cells were cultured in a cell incubator with 5% CO2 at 37 °C under humidified conditions. RNA extraction and quantitative PCR Total RNA was extracted from the cell and tissue samples using TRIzol reagent (Technologies, USA) and a RNeasy Mini kit (Qiagen, Germany) following...
Here, it was reported that GC-derived LBP drives the formation of intrahepatic fibrotic PMN by inducing TGF-β1 secretion in intrahepatic macrophages to promote GC-LM. Methods Human tissue and serum samples IHC staining of LBP and TGFBR1 was performed in the tissues obtained from primary GC ...
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Transforming growth factor-β (TGF-β) is a potent stimulus of connective tissue accumulation, and is implicated in the pathogenesis of scleroderma and oth... G Lakos,S Takagawa,SJ Chen,.....
A. Role of connective tissue growth factor in breast implant elastomer capsular formation. Ann. Plast. Surg. 50, 263–268 (2003). Article PubMed Google Scholar Park, S. et al. Acute suppression of TGF-β with local, sustained release of tranilast against the formation of fibrous capsules ...
Fibulin-6, the largest member of the fibulin family has been characterized in the process of MR by our group14. It is known for its role in the formation of transient cell contacts during tissue organization, cell migration, basement membrane invasion as well as in the formation of stable ...
Fibrosis may occur in response to physical or chemical injury as part of a reparative or reactive process, also referred to as scarring. Fibrosis may also arise from a pathological aberration in a cell or tissue without external injury. Fibrosis results in the deposition of connective tissue, ...