S. et al. Association between fibrosis stage and outcomes of patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. Gastroenterology 158, 1611–1625 (2020). Article CAS PubMed Google Scholar Moon, A. M., Singal, A. G. & Tapper, E. B. Contemporary ...
For the transfer learning approach, we used a pre-trained deep learning neural network to stage the liver fibrosis samples (AUROC = 0.93 for Stage 0 vs. 1, 2, 3 and 4, AUTOC = 0.85 for Stage 0 and 1 vs. 2, 3 and 4, AUTOC = 0.95 for Stage 0, 1 and 2 vs. 3 ...
32,33,34]. Thus, ASL, a noninvasive fMRI technique, has been implemented to reliably quantify RBF, promising to improve early-stage detection of CKD [32,33,34]. This technology uses water in arterial blood as an endogenous tracer with which to map...
Re-evaluation of fibrogenic cytokines in lung fibrosis. Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung disease which results in end-stage fibrosis. The pathogenesis is believed to be related ... M Kelly,M Kolb,P Bonniaud,... - 《Current Pharmaceutical Design》 被引量: 493...
Given that d21 in the mouse model reflected an established stage of fibrosis with minimal acute inflammation, we focused on this time point for comparison with IPF. NMF application to the mouse d21 data (mmNMFd21) generated 30 factors (Supplementary Table9). Factor activity and cell-type abun...
The aim of this study was to compare the results of nine non-invasive serum biomarkers with liver biopsies to predict liver fibrosis stage. HCV-RNA-positive, HCV genotype 1, treatment-naive patients with chronic HCV infections were included from 14 centers ( n =77). The platelet count, AST...
Post hoc sensitivity analyses repeated the Cox regression for the primary outcome, first with the 44 clinical centers incorporated as a stratification factor (leading to a total of 88 strata when combined with the fibrosis stage strata), and then using a γ frailty model in which center was ...
S19k). Altogether, nanoparticle delivery of Foxf1 cDNA into endothelial cells on the day of bleomycin injury or during fibrotic stage after the injury inhibits pulmonary fibrosis and improves mice survival. Discussion Significant changes in gene expression among epithelial and mesenchymal cellular ...
OBJECTIVES: We conducted an individual participant data (IPD) pooled analysis on diagnostic accuracy of MRE to detect fibrosis stage in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: Through a systematic literature search, we identified studies of MRE (at 60-62.5 Hz) for st...
Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung. Fibrosis such as liver cirrhos