circumstances.By manipulation of the diet, a wide diversity of liver pathologies has been produced, analogous to that seen in malnourished communities.An explanation has been offered to account for the differences in reactivity of the liver to nocuous stimuli such as the virus of infective hepatitis...
To date, the majority of research on hypercholesterolemia has focused on the effects of a high cholesterol diet on atherosclerosis and coronary heart disease. The toxic effects of cholesterol on the liver and the relationship between the intake of a high cholesterol diet and hepatic fibrosis, howeve...
Pathogenesis of schistosomal ‘pipestem’ fibrosis: a low‐protein diet inhibits the development of ‘pipestem’ fibrosis in mice Mice maintained on a low protein diet for 30 days and then infected with for 16 weeks completely failed to develop 'pipestem fibrosis' of the liver, wherea... EM...
inhibition ofHSCactivation plays a vital role in the prevention ofliver fibrosis.Buteinwas proved to successfully inhibit the activation of HSCs through thedownregulationof expression and activation of α-SMA, TGF-β, TIMP-1, TIMP-2, MMP-2, NF-κB,MAPK, andJNK(Szuster-Ciesielska et al., 201...
Heterozygous WHHL rabbits were fed a cholesterol enriched diet with added vegetable oil or marine oil for 14 weeks. All rabbits developed varying degrees of liver fibrosis, which was most severe in the cholesterol/marine oil fed group. In all groups the pattern of fibrosis was very similar to ...
However, the roles o... K Jiang,S Lu,D Li,... - 《Journal of Gastroenterology》 被引量: 0发表: 2023年 Adipose tissue insulin resistance exacerbates liver inflammation and fibrosis in a diet-induced NASH model Background:Insulin regulates various biological processes in adipocytes, and adipose...
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Since the ethanol diet fed ad libitum with such a low level of fat has previously failed to produce alcoholic fatty liver, continuously high blood alcohol levels achieved in this model appeared to be key in induction of the progressive pathologic lesions in the liver. In the current study, ...
Since the ethanol diet fed ad libitum with such a low level of fat has previously failed to produce alcoholic fatty liver, continuously high blood alcohol levels achieved in this model appeared to be key in induction of the progressive pathologic lesions in the liver. In the current study, ...
However, the knockout of NLRP3 reversed these patterns. Conclusion (1) Primary conjugated bile acids increased in patients with liver fibrosis; (2) GCDCA induce hepatic fibrosis via the NLRP3 inflammasome pathway; (3) FXR inhibits NLRP3 activity by restraining its phosphorylation; (4) knockdown...