Thrombin (EC 3.4.21.5), a serine protease, generated by proteolytic cleavage of prothrombin (Factor II) through the concerted action of several enzymes and cofactors (1) has many effects on the hemostatic system including conversion of fibrinogen to fibrin (Fig. 1), activa-tion of Factors V,...
Formation of fibrin is triggered by thrombin cleavage of fibrinopeptides A and B from the N-termini of the Aα and Bβ chains of fibrinogen (Fig. 2a). Removal of the fibrinopeptides exposes “knobs” that bind to “holes” in the γ- and β-nodules to initiate fibrin fiber formation...
[translate] asillky sillky [translate] apenetrate 击穿 [translate] aThrombin converts inactive fibrinogen into fibrin, leading to thrombus formation. 凝血酶转换不活泼的纤维蛋白原成纤维蛋白,导致血栓形成。 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 ...
Blood coagulation ultimately depends on the thrombin-induced conversion of fibrinogen to fibrin1,2. Fibrinogen is a dimeric symmetric macromolecule. Each half consists of three different polypeptide chains, Aα, Bβ and γ, linked together by disulphide bridges. The two sets of chains are connected...
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not suf...
These domains contain constitutive binding sites that participate in fibrinogen conversion to fibrin, fibrin assembly, cross linking, and platelet interactions (e.g., thrombin substrate, Da, Db, gamma XL, D:D, alpha C, gamma A chain platelet receptor) as well as sites that are available after...
Non-Newtonian flow and transverse wave propagation have been studied in solutions of intermediate polymers of bovine fibrinogen, formed by thrombin at pH 9.4, ionic strength 0.5, in the presence of 0.5 M hexamethylene glycol. The results conform approximately to the behavior of rigid rods or elonga...
The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes ...
Thrombin catalyzes the conversion of fibrinogen to fibrin by cleaving, in sequence, the N-termini of the α chain, releasing fibrinopeptide A (FpA), and the β chain, releasing fibrinopeptide B (FpB) (Lord, 2007; Wolberg, 2007). Removal of the fibrinopeptides exposes polymerization sites ...