AllinkBio旨在为肿瘤学和免疫学疾病领域的患者开发治疗范式转变的新药,并解决全球关键的未满足医疗需求。 来源|Antibody Research
Wainberg explained that bemarituzumab is an IgG1 antibody targeted specifically to the FGFR2b receptor to block growth factor signaling. The findings from FIGHT suggest FGFR2b is a new biomarker and therapeutic target for advanced gastric and GEJ cancers. "The FIGHT trial results support a prosp...
Thus, GB2102 may represent a differentiated antibody therapeutics that has a potential to decrease the adverse effects in the eyes. Methods: GB2102 was generated by immunization of FGFR2b protein in mice followed by hybridoma technique. FGF7 and FGF10 ligand blocking was assessed by ELISA. FGF...
对抗体和其抗原结合片段工程改造以改善与FcRn的结合亲和力的方法是本领域中众所周知的,参见例如Vaughn,D.等人《,结构(Structure)》,6(1):63‑73(1998);Kontermann,R.等人《,抗体工程(Antibody Engineering)》,第1卷,第27章:改善PK的Fc区工程改造(Engineering of the Fc region for improved PK),Springer出版...
Basic informationMore Product Name:FGFR2 antibody Synonyms: CAS: MF: MW:0 EINECS: Mol File:Mol File Browse by Nationality Suppliers>Global suppliers Shanghai (4)Chongqing (1)Hubei (1)Jiangsu (1)Member(7)All (7) Please select the suppliers ...
Product Name:Anti-FGFR2 Antibody Synonyms:Anti-FGFR2 Antibody CAS: MF: MW:0 EINECS: Mol File:Mol File Browse by Nationality Suppliers>Global suppliers Beijing (4)Shanghai (3)Fujian (1)Jiangsu (1)Jiangxi (1)Other (1)Member(11)All (11) ...
Background: In the FIGHT study (NCT03694522) bemarituzumab, a humanized monoclonal antibody selective for fibroblast growth factor receptor 2b (FGFR2b), plus mFOLFOX6 showed clinically meaningful efficacy in patients with FGFR2b-positive (2+/3+ membranous staining by immunohistochemistry) locally ...
2. Gemo AT, et al. FPA144: Atherapeutic antibody for treating patients with gastric cancers bearing FGFR2gene amplification. Cancer Res. 2014;74(19 Suppl). (作者:张洪涛,笔名“一节生姜”。宾夕法尼亚大学医学院病理及实验医药系研究副教授,研究领域:癌症的靶向治疗以及免疫治疗。著有科普读物:《吃什...
Bemarituzumab is an IgG1 antibody that is specific for FGFR2b isoform, which blocks growth factor signaling and works through an antibody-dependent cellular cytotoxicity mechanism, said Wainberg. Prior single-agent activity with bemarituzumab in later-line FGFR2b-positive gastric cancer...
Anti-FGFR2 Polyclonal Antibody|ANTI-FGFR2 POLYCLONAL ANTIBODY 基本信息 更多信息 中文名称: ANTI-FGFR2 POLYCLONAL ANTIBODY 中文同义词: 英文名称: Anti-FGFR2 Polyclonal Antibody 英文同义词: Anti-FGFR2 Polyclonal Antibody CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览...