近来有研究发现,没有CKD的普通人群,FGF23与CVD和死亡率也存在梯度关系,即使在肾功能保存(preserved renal function)的个体中。总之,这些研究表明FGF23可以作为一个预测不良临床结局的新型生物学标志物,尤其对CKD患者。 FGF23是一个生物学标志物?是疾病进展的帮凶? FGF23与...
临床上,安大略省西部和麦克马斯特大学关节炎指数僵硬度分量表评分(Western Ontario and McMaster Universities Arthritis Index stiffness subscale score)有所改善,SF-36生活质量问卷的最差疼痛评分(Worst Pain Score)和身体功能亚评分(Physical Function sub-score)也有所改善146,147,148,149,150。在一项随机、双盲、安...
临床上,安大略省西部和麦克马斯特大学关节炎指数僵硬度分量表评分(Western Ontario and McMaster Universities Arthritis Index stiffness subscale score)有所改善,SF-36生活质量问卷的最差疼痛评分(Worst Pain Score)和身体功能亚评分(Physic...
1.National Kidney Foundation.National Kidney Foundation 2022 Spring Clinical Meeting Abstracts. ASSOCIATIONOF FGF23 WITH KIDNEY FUNCTION IN YOUNG ADULTS. AJKD. 2022 April. 2.AgoroR, Ni P, Noonan ML, White KE. Osteocytic FGF23 and Its Kidney Function. FrontEndocrinol (Lausanne). 2020 Aug 28;1...
The Fibroblast Growth Factor-23 (FGF23) gene resides on human chromosome 12p13 (mouse chromosome 6). It comprises three coding exons and contains an open reading frame of 251 residues. FGF23 has overlapping function with PTH to reduce renal Pi reabsorption, but it has the opposite effects on...
作者签名:挚导师签名:南京医科大学博士学位论文FGF.23过表达经磷介导引起中枢神经系统和心血管系统功能异常博士研究生刘培党导师王鹤鸣教授苗登顺教授中文摘要成纤维细胞生长因子(FGF).23属于FGF.19亚科,是多肽激素FGF家族的新成员。FGF.23蛋白由251个氨基酸残基组成,其氨基端的24个氨基酸形成信号肽,因此,FGF.23属于分泌...
Exercise has been shown to improve endothelial function and reduce oxidative stress, while dietary modifications such as increased consumption of fruits, vegetables, and omega-3 fatty acids may reduce inflammation and improve lipid profiles. In conclusion, atherosclerosis is a major complication of Type...
Nakatani, T., Ohnishi, M. & Razzaque, M. S. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model.FASEB J.doi:10.1096/fj.08-123992. ...
3:133一143. rats.Joumal Ameri哪socie竹ofNephfolo盱,2006, 15 Bi粕chi S,Bigazzi 17:1362一1372. R,C栅f,e鸵VM.kIlg—te姗e眠tsof叩iM肛 Iactoneon in withchmnic22 C.LocalfenaIaId鸺terone induc船in. function HM,Xue proteinuria卸dkidney pati朋ts Siragy production intemational,2006,70:2l16...
Chronic kidney diseaseVascular calcificationFibroblast growth factor 23(FGF23)is a protein synthesized by bone cell and the osteoblast with endocrine function.The main role of FGF23 is to regulate serum phosphorus and 1,25(OH)2 D3 levels,it also plays an important role in calcium and phosphorus...