Here, we investigated the roles of FGF21 and SCs in DC-related sarcopenia as well as the underlying mechanisms. Methods We developed two DC mouse models and performed in vivo and in vitro experiments. Klotho beta (KLB) knockout mice in SCs were constructed to investigate the role of KLB ...
leucocholic acid, which may suggest a possible mode of delivery for microbially-generated AAs in the gut for host uptake38. This line of investigation could improve dietary recommendations for those consuming low-protein diets, and furthermore provide insight into delaying sarcopenia and treating ...
a hepatokine that increases brown and subcutaneous inguinal white adipose tissues (BAT and iWAT, respectively) uncoupling protein 1 (UCP-1) content, thermogenesis and energy expenditure. Herein, we tested the hypothesis that an enhanced BAT and iWAT UCP-1-mediated thermogenesis induced...