Our results demonstrated that liver index and liver function were deteriorated in both models. Hematoxylin and eosin and Masson's staining showed that the damaged tissue architectonics were observed in the mice of both models. Treatment with FGF21 significantly ameliorated these changes. ELISA ...
Mladenović D, Radosavljević T, Hrnčić D, Rasic-Markovic A, Stanojlović O. The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain - implications for longevity. Rev Neurosci. 2019;30(6):581-93. Ables GP, Johnson JE. Pleiotro...
FGF21 improved glucose tolerance and liver insulin sensitivity in Zuckers without affecting BW and improved liver function by decreased lipogenesis, increased fatty acid oxidation and improved insulin signaling. Through detailed lipidomic analyses of liver metabolites in DIOs, we demonstrate that FGF21 ...
In mice, FGF21 reduces alcohol intake, and human Fgf21 variants are enriched among heavy drinkers. Thus, the liver may limit alcohol consumption by secreting FGF21. However, whether full-length, active plasma FGF21 (FGF21 (1–181)) levels in humans increase acutely or sub-chronically in ...
Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator expressed in multiple tissues including liver and adipose tissue. Although highest levels of expression are in pancreas, little is known about the function of FGF21 in this tissue. In order to understand the physiology...
1. Deficiency of hepatocyte MR improves cardiac function and decreases infarct scar size after acute or subacute MI in mice 为了筛选参与心肝交互的核受体,作者对MI或sham小鼠的肝脏进行了转录组测序,518个差异基因中有30个转录因子,其中有3个核受体Nr1d1, Nr1d2和Nr3c2(a)。Nr3c2也就是盐皮质激素受体...
FGF21 is an inducible hepatokine and could be a biomarker for normal hepatocyte function. Activation of its expression is a response of functional hepatocytes to a broad spectrum of pathological changes that impose both cellular and metabolic stress on the liver. Taken together with our recent data...
Objective: In the first part of this study, it was found that FGF21 levels were elevated at the stage of simple steatosis in NAFLD patients and were not associated with hepatocellular inflammation and liver injury. Therefore, FGF21 may be involved in the regulation of systemic glucose metabolism...
FGF21 belongs to an atypical subfamily, which lacks the conventional FGF heparin-binding domain, and thus FGF21 can diffuse away from the tissues of production and function as an endocrine factor (Ogawa et al. 2007). Nishimura’s team first cloned the human and mouse FGF21 genes in 2000 ...
In the liver, FGF21 plays an important role in the regulation of fatty acid oxidation both in the fasted state and in mice consuming a high-fat, low-carbohydrate ketogenic diet. FGF21 also regulates fatty acid metabolism in mice consuming a diet that promotes hepatic lipotoxicity. In white ...