With these data, we used a data-driven model that identified three distinct lung function trajectories with different outcomes in terms of both initial FEV1, subsequent FEV1 decline, and mortality. Subjects in one of these trajectories, referred to as airway obstruction trajectory 2 in the article...
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FEV1/FVC increased in early adolescence, but at age 16, was 5.6% lower in male children compared to healthy children, and 5.4% lower in females. The ratio was lower in obese children at all ages but demonstrated the same curvilinear shape as healthy children. In absolute terms, FEV1 grew ...
These data suggest that the evening peak in lung function with formoterol was not manifested in terms of advantages in night-time symptomatology. Treatment with both doses of olodaterol and formoterol was well tolerated and incidence of AEs across treatment groups was comparable with the most ...
These data suggest that the evening peak in lung function with formoterol was not manifested in terms of advantages in night-time symptomatology. Treatment with both doses of olodaterol and formoterol was well tolerated and incidence of AEs across treatment groups was comparable with the most ...
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Decline in FEV1 per year among the three groups. AHI, apnoea-hypopnoea index; *p < 0.05 compared to AHI <5; + p < 0.05 compared to 5 ≤ AHI < 30 Full size image In terms of possible aetiologies responsible for the annual decline of FEV1, % from baseline, univariate...
More specifically, one of the most recent studies found that the decline of KCO was associated with disease severity in terms of airflow limitation and emphysema, as well as with an accelerated decline in FEV1, more frequent exacerbations, thus reflecting worse disease outcomes85. Besides, a ...
presenting the results in terms of average FEV1decline per year (beta) assume that the rate of decline is approximately constant over time, an assumption which is supported by the analyses presented in Table5. Though this analysis is uncertain, being ecological in nature (as the relationship of...
The regression model for subject i at interval t can be writ- ten as: E(∆FEVit) = b1 ×(Height)it + b2 ×(Age terms)it + b3 ×(smoking variables)it + b4 ×(area)i where ∆FEVit=(FEVi,t+1 - FEVi,t)/(Agei,t+1 - Agei,t); b1, b2, b3, and b4 are the vectors ...