A.在治疗期第一天,在给药前(基线)、给药后1,2,3,4,5,6,8,10,12小时(时间窗±15min)分别进行FEV1的测量 B.在治疗期第一天,在给药前(给药前30min内)和用药后第0.5 h(±5min)、1 h(±10min)、2 h(±10min)、3 h(±15min)、4 h(±15min)、6 h(±30min)、8 h(±30min)、10 h(±...
The mean absolute, and similarly relative, maximum reductions in FEV 1 compared with post-diluent baseline values demonstrated lower intra-subject variability (incremental 21.16%, bolus 40.67%) than the FEV 1 AUC 0-tz -based endpoint. There was a trend towards faster recovery following the bolus...
Table 4 Adjusted mean FEV 1 AUC 0–3 , peak FEV 1 , and trough FEV 1 responses (L) compared to placebo after 6 weeks Full size table The corresponding FVC responses after 6 weeks’ treatment with olodaterol 5 and 10 μg QD and formoterol 12 μg BID were consistent with the FEV1 ...