A. Schematic depiction of magnetic fluid hyperthermia mechanism of action. The upper image shows the specific accumulation of magnetic nanoparticles (MNP) in tumor tissue due to leaky vasculature (EPR). The lower image exemplifies that after the application of an alternating current (AC) magnetic ...
Mechanism Of Action Feraheme consists of a superparamagnetic iron oxide that is coated with a carbohydrate shell, which helps to isolate the bioactive iron from plasma components until the iron-carbohydrate complex enters the reticuloendothelial system macrophages of the liver, spleen and bone marrow....
HO-1, an integral component of an important cytoprotective mechanism, mediates its action through removal of heme, the generation of heme breakdown reaction products (biliverdin, free iron, and carbon monoxide), and modulation of key cellular molecules. Data from experimental models in which HO-1...
death (Fig. 4) [92]. Ferumoxytol treatment significantly reduces the disease burden in themouse leukemiamodel, as well as patient-derived xenografts of leukemia cells with lowferritinexpression [39]. The mechanism of action of ferumoxytol in destroying cancer cells may be associated withferroptosis....