联合吴自俊所在的加拿大渥太华大学德里克·普瑞特(Derek Pratt)教授的实验室,在研究细胞铁死亡的调控体系时发现,铁死亡抑制蛋白-1(FSP1,ferroptosis suppressor protein 1)是独立于谷胱甘肽过氧化物酶 4 的铁死亡抑制体系。
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing...
在癌症研究领域中,Ferroptosis suppressor protein 1(FSP1)和Glutathione peroxidase 4(GPX4)已成为重要研究靶点。FSP1和GPX4作为细胞铁死亡通路的负调节因子,阻碍细胞铁死亡。其FSP1和GPX4抑制剂则能有效激活癌细胞的铁死亡,该类抑制剂的药物筛选也已成为研究新型抗癌治疗方法的热点项目。 Ferroptosis分子机制与信号通路图:...
2019年,Marcus Conrad博士及其研究团队已经确定了一种酶是一种新型的、强有力的铁死亡抑制剂:FSP1(ferroptosis suppressor protein-1, 铁死亡抑制蛋白1)。他们如今发现,完全还原形式的维生素K(vitamin K hydroquinone,维生素K氢醌)作为一种强大的亲脂性抗氧化剂起作用,通过在脂质双层中捕获氧自由基来阻止铁中毒。此外,...
Ferroptosis Suppressor Protein 1 (FSP1)BACKGROUND. There are currently no proven therapies for metastatic or unresectable Chromophobe renal cell carcinoma (ChRCC). Ferroptosis is an iron-dependent form of cell death characterized by the peroxidation of membrane polyunsaturated fatty acids, leading to ...
by ferroptosis suppressor protein 1 (FSP1) [16]. In the inner mitochondrial membrane, CoQH2 can be reduced from CoQ by dihydroorotate dehydrogenase (DHODH) to scavenge lipid peroxides and inhibit ferroptosis [17]. (3) Tetrahydrobiopterin (BH4) biosynthesis is catalyzed by a series of enzymes, ...
Ferroptosis suppressor protein 1 CoQ10: Coenzyme Q10 GCH1: GTP cyclohydrolase 1 BH4: Tetrahydrobiopterin SLC7A11: Solute carrier family 7 member 11 SLC3A2: Solute carrier family 3 member 2 GCL: Glutamate-cysteine ligase Nrf2: Nuclear factor erythroid 2-related factor 2 ...
AIFM2 was recognised as an anti-iron porphyrin gene and was later renamed ferrocyte apoptosis suppressor protein 1 (FSP1). FSP1 inhibits iron through ubiquitin ketone (CoQ10), a reductant that scavenges the lipid peroxyl radicals responsible for lipid peroxidation. The use of FSP1 as a pharma...
demonstrated that NADPH was used to regenerate CoQH2 by ferroptosis suppressor protein 1 (FSP1), which restrains ferroptosis [16]. Consistent with these findings, other studies confirmed that NADPH was used to generate NO, which suppressed ferroptosis [48, 49]. Otherwise, NADPH contributes to ...
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis Ferroptosis suppressor protein 1 (FSP1) is a newly identified suppressor for ferroptosis. This study aims to investigate the role of FSP1 in IDD. ... C Qiu,L Cheng,D Di,... - 《...