. Infection in humans with SARS-CoV-2 can lead to severe disease, hospitalization, and death in some cases while others may remain subclinical or develop only mild disease; therefore, the clinical picture of COVID-19 is significantly varied and disease can range from mild nasal congestion and ...
The majority of studies of IAV host species adaptation has focused on the type of linkage between the sialic acid and the penultimate galactose residue, SAa2,6Gal or SAa2,3Gal, and the distribution of these receptors in the host9,10. The susceptibility of ferrets for human IAV strains has...
[H3N2] by 6 log cycles, and avian reassortment influenza A/Washington/897/80 X A Mallard/New York/6750/78 [H3N2] by 5 log cycles, with 1 min contact./p pTwo ferret challenge studies, with influenza A Sydney/5/97, demonstrated a reduction in the severity of the disease with early ...
RNA-qPCR analysis of BAL samples taken during and after IAV infection of ferrets for expression levels of selected pro-inflammatory and wound-healing cytokines relative to those prior to exposure suggested that respiratory tissues of IAV-experienced animals may be in an anti-inflammatory state at the...
remdesivir is a mono-phosphoramidate prodrug of a ribonucleoside analog that must be administered intravenously3. The obligatory parenteral delivery limits access of COVID-19 outpatients to remdesivir treatment, thereby narrowing the therapeutic window in which a direct-acting antiviral targeting an acute...
(Fig. 1b), demonstrating that sialic-acid residues are present on serum glycoproteins in all species. The same serum samples were analysed by high-performance liquid chromatography to quantitate the amount and type of sialic acid present. Both ferret and human serum had Neu5Ac, but no ...