[2] Tuo QZ, et al. Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion. Signal Transduct Target Ther. 2022 Feb 23;7(1):59. Ver.CN20230321
实时荧光定量逆转录PCR(RT-qPCR)检测铁死亡特异性基因长链脂酰辅酶A合成酶4(ACSL4),前列腺素内过氧化物合成酶2(ptgs2)转录水平.Western-blotting检测谷胱甘肽过氧化物酶4(GPX4),二氢乳清酸脱氢酶(DHODH)表达水平.结果:与Sham组相比,I/R组AST,ALT,ACSL4 mRNA,ptgs2mRNA,MDA水平显著升高(p<0.05),GSH水平下降(...
RESULTS :We found that Umbelliferone can significantly improve the renal pathological damage and ROS accumulation of db/db mice, and inhibit ferroptosis, such as the down-regulation of ACSL4 and the up-regulation of GPX4. Meanwhile, Nrf2 and HO-1 expression were up-regulated. We demonstrated ...