Symptom onset generally occurs within several hours to a few days of concomitant use but may occur later. If concomitant use of other serotonergic drugs is warranted, monitor patients for serotonin syndrome, particularly during initiation of therapy and dosage increases. If serotonin syndrome is suspec...
Janssen developed fentanyl by assaying analogues of the structurally-related drug pethidine for opioid activity.[8] The widespread use of fentanyl triggered the production of fentanyl citrate (fentanyl combined with citrate at a 1:1 ratio),[9] which entered the clinical practice as a general ...
Hiccups are almost like a domino effect in the body. First, the diaphragm experiences asudden and involuntary contraction. That causes the vocal cords to close, which then creates that “hic” yelping sound to come out of the throat. While hiccups can be asymptom of a medical disorder, the...
Lehmann KA, Zech D. Transdermal fentanyl: clinical pharmacology. J Pain Symptom Manag. 1992;7(3 Suppl.):S8–16. ArticleCASGoogle Scholar Delgado-Charro MB, Guy RH. Effective use of transdermal drug delivery in children. Adv Drug Deliv Rev. 2014;73:63–82. ...
Symptom onset generally occurs within several hours to a few days of concomitant use but may occur later. If concomitant use of other serotonergic drugs is warranted, monitor patients for serotonin syndrome, particularly during initiation of therapy and dosage increases. If serotonin syndrome is suspec...