These results demonstrate that fenretinide treatment after SCI can reduce inflammation and tissue damage in the spinal cord and improve locomotor recovery. These beneficial effects may be mediated via the ability of fenretinide to modulate PUFA homeostasis. Since fenretinide is currently in clinical...
However the pathophysiology of spinal cord injury (SCI) is far from clear. Recently, a close association between spinal 5HT level and severity of injury has been suggested by several investigators. Mianserine, a 5HT antagonist has been shown to enhance the recovery from neurotrauma. Fenfluramine...
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