A combination of two drugs, fenfluramine hydrochloride and phentermine, formerly prescribed for weight loss but withdrawn from the market in 1997 because of potentially dangerous side effects. The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by...
The overall safety pattern of fenbufen has been evaluated in a total of 2,667 patients: 1,667 of them in domestic clinical studies and 1,000 in foreign pivotal studies. Comparisons of several hundred patients鈥攅ach receiving aspirin, indomethacin, and placebo鈥攚ere made. Detailed analysis ...
visceral, and skeletal) at the highest dose tested, which was associated with maternal toxicity. At the no-effect dose (8.6 mg/kg/day) for adverse effects on embryofetal development
Greenwood, M.: Side-effects associated with long-term fenfluramine therapy. La Vie Medicale au Canada Francais 2: 248 (1973). PubMedCAS Gunne, L.M.; Antonijevic, S. and Jonsson, J.: Effect of fenfluramine on steady state plasma levels of amitriptyline. Postgraduate Medical Journal 51 (...
6. Adverse Reactions/Side Effects The following adverse reactions are discussed in greater detail in other sections of the labeling: Cardiovascular Thrombotic Events [ see Warnings and Precautions ( 5.1) ] GI Bleeding, Ulceration and Perforation [ see Warnings and Precautions ( 5.2) ] Hepatotoxi...
Furthermore, FEN1 inhi- bitor impeded the progression of lung cancer and resulted in an accumulative effect when combined with cisplatin in vitro and on xenograft tumor mice models. Our work showed that targeting FEN1 could be a potential strategy for lung cancer therapy. 2. Materials and ...
It has a low incidence of serious GI side effects probably because it is a pro-drug and has little effect on bleeding time. Experience to date has not revealed any propensity to seriously damage the bone marrow or liver or cause any other serious side effects. If widespread use confirms ...
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy. OBJECTIVE: To determine whether the severity of valvulopathy was associated with the dosage of fenfluramine taken by fenfluramine-phentermine users with va... Serdula,M K,Willia...
In order to get out the same effect as the previous snippet we first need to make a call to glBindVertexBuffer. Despite Bind being in the name it isn't the same kind as for instance: glBindTexture. Here's how they're both put into action: struct vertex { vec3 pos, nrm; vec2 ...
These authors have also studied the effect of hydrotalcite (well as an additive or as a hosting matrix) on the solubility of fenbufen at different pH values. They find that the presence of Mg, Al-LDH as an additive increases the solubility by 51, 62, and 21%, respectively, at pH 1.2...