In this study, we found a novel regulatory mechanism of miR-21, the feedback loop of miR-21/VMP1 (Fig. 7). The expression of miR-21 is negatively correlated with VMP1 in CRC cells, and VMP1 inhibits miR-21 expression at the transcriptional level because of their special locations in ...
These previous data brought us an idea that the establishment of nucleus-mitochondria positive feedback loop induced by chemo-radiation may play a key role for inducing persistent and irreversible SASP. To the best of our knowledge, we could not find any paper even review, except for ours, ...
Anoikis resistance is an essential prerequisite for tumor metastasis, but the underlying molecular mechanisms remain unknown. Herein, we report that the oncoprotein hepatitis B X-interacting protein (HBXIP) is prominently upregulated in breast cancer cel
ERp57 dysfunction has been shown to contribute to tumorigenesis in multiple malignances. However, the role of ERp57 in clear cell renal carcinoma (ccRCC) remains unclear. Cell proliferation ability was measured by MTT and colony forming assays. Western b
A recent study suggests that oxidative stress is involved in the fine-tuning of the autophagic process in response to the level of oxidative stress and functions in a feedback loop (Tang et al., 2019). We performed siRNA-mediated silencing of p62 and Nrf2 to further investigate the relationsh...
metabolism but also stimulates cancer cell apoptosis. In addition, the positive feedback loop between miR-124 and PKM1/HNF4α plays an important role in colorectal cancer cell apoptosis; it suggests that disrupting this regulatory circuit might be a potential therapeutic tool for colorectal cancer ...