In a regulatory process called feedback inhibition, the product of a reaction inhibits an enzyme at an earlier step in the metabolic pathway that produced it. The product binds to a regulatory site on the enzyme, which is distinct from the active site that binds to the substrate, thereby slo...
G. Dohlman, A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr. Biol. 17, 659-667 (2007).N. Hao, M. Behar, S. C. Parnell et al., "A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress- response pathway," ...
It was found that group Ib inhibition was significantly decreased, and the occurrence of polysynaptic group I excitation was more frequent in extensor motoneurons because of training (Cote et al., 2003). These changes may help the recruitment of extensor muscles involved in weight-bearing during ...
Evidence of inhibition in auditory cortical areas in the superior temporal gyrus during one's own speech comes from several different sources, including recorded neural responses during open-brain surgery (Creutzfeldt et al., 1989), magnetoencephalography (MEG) measurements (Numminen and Curio, 1999;...
it is essential to enrich the toolbox of available network motifs with negative feedback loops where thiols would trigger their elimination (Fig.1b)12. These motifs would provide negative feedback that is more nonlinear than direct inhibition and enable oscillators with tunable frequency11,18, adap...
However, in contrast to Nassi et al., we found that feedback inactivation also caused an increase in sRF size, and this could not be accounted for by a model in which feedback only affects the spatial extent of surround inhibition. Instead, we found that a model involving changes in the...
Such conditions proved to be pretty straightforward in their application in the presence of a y-independent activation function f (Corollary 1), and in the presence of an x-independent inhibition function g (Corollary 2); in the last case, a simple graphical procedure allows to determine the ...
Different studies have identified a decrease in hemispheric lateralization associated with the cognitive demands during controlled inhibition [26], conflict resolution [27], and memory [28]. Asymmetric brain activation can also lead to differential FC in the two hemispheres. In general, the rationale ...
theta oscillations also could have supported motor consolidation by sharpening memory representations that compete for retrieval. It has been suggested that theta oscillations reflect varying levels of inhibition strength that lead to strengthening of target memories while competing memories are being suppresse...
Cite this article Galoian, K., Temple, H.T. & Galoyan, A. mTORC1 inhibition and ECM–cell adhesion-independent drug resistance via PI3K–AKT and PI3K–RAS–MAPK feedback loops.Tumor Biol.33, 885–890 (2012). https://doi.org/10.1007/s13277-011-0315-x ...