Sharp arrows represent activation; dull arrows represent inhibition. Full size image Motivated by this question, we explored the selenium-catalyzed oxidation of thiols with organic peroxides. This reaction enabled the construction of negative feedback loops that, when combined with autocatalysis (Fig. 1...
Indeed, induction of EMT led to an increase in GABARAPL1 levels through the activation of the SMAD signaling pathway, and then GABARAPL1 induced the autophagy-selective degradation of SMAD proteins, leading to EMT inhibition. Keywords: autophagy; ATG8; GABARAPL1; cancer; EMT; SMAD ...
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Different studies have identified a decrease in hemispheric lateralization associated with the cognitive demands during controlled inhibition [26], conflict resolution [27], and memory [28]. Asymmetric brain activation can also lead to differential FC in the two hemispheres. In general, the rationale ...
For example, when the inhibition of v1 and v2b interneurons is absent, the flexor and extensor motoneurons can still be synchronously and rhythmically excited [24–26]. Although the introduction of this connection increases the explanatory power of this model, how the strength of this connection...