The clearance of stressed cells via the NKG2D/NKG2D ligand pathway is a double-edged mechanism since many abnormal cells, such as transformed and infected cells, can escape apoptotic cleansing by releasing NKG2D ligands from their cell surfaces (Fig. 1). There are two ways to dispose NKG2D ...
We propose that a feed-forward regulatory mechanism exists between ARIH2 and PABPN1 that is aging regulated and is prominent in skeletal muscles. In support, masking the proximal PAS in ARIH2 3′-UTR by antisense oligonucleotides (AONs) in PABPN1 down-regulated cells elevates the expression of...
Targeting the dominant mechanism of coronary microvascular dysfunction with intracoronary physiology tests The coronary microcirculation plays a key role in modulating blood supply to the myocardium. Several factors like myocardial oxygen demands, endothelial an... H Mejía-Rentería,VDH Nina,dHTP Van,....
Collectively, these findings support a mechanism in which NGF deprivation, Akt dephosphorylation/inactivation, FoxO dephosphorylation/activation and Trib3 induction are linked in a self-amplifying feed-forward loop that culminates in neuron death. This is a preview of subscription content, access via ...
A mechanism is proposed through which parallel processing and lateral inhibition in the forward direction can enhance spatial resolution at the thalamic level. 展开 关键词: Theoretical or Mathematical/ neural nets neurophysiology visual evoked potentials/ feedforward inhibition visual thalamus anatomical data...
Indeed, figure-ground segregation can happen rapidly and is seemingly in part feedforward and apparent already at the earliest stages of visual cortical processing in V162. Laminar evidence is also consistent with this notion63. And while we can only speculate as to the exact mechanism producing ...
Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex. Journal of Physiology 588, 2769-2787.Kimura F, Itami C, Ikezoe K, Tamura H, Fujita I, Yanagawa Y, Obata K, Ohshima M (2010) Fast activation ...
Under hypoxic conditions, enhanced β-catenin and Nur77 expression synergistically stimulated CRC cell migration, invasion, and epithelial-mesenchymal transition.Conclusion:These findings provide a novel molecular mechanism for hypoxic CRCs that may contribute to tumour progression, and its targeting may ...
Although our initial models captured the integration characteristics of IB neurons, no combination of parameters reproduced the physiology of RS cells. This suggested the presence of an additional, non-cell-autonomous mechanism. Feedforward inhibition may control the temporal window for synaptic integration...
Sensory processing is distributed among many brain regions that interact via feedforward and feedback signaling. Neuronal oscillations have been shown to mediate intercortical feedforward and feedback interactions. Yet, the macroscopic structure of the m