Fracture of the posterior vertebral endplate is a cause of low back pain in adolescents and young adults. Clinically it resembles an acute disc prolapse with low back pain and radiculopathy, but may present with neurogenic claudication due to spinal stenosis in older patients. The lesions may be...
The CreERT2 fusion protein is engineered to be anchored in the cytoplasm through binding with heat shock protein 90 (Hsp90)28. In the presence of 4-hydroxytamoxifen (4-OHT) Hsp90 releases CreERT2 which is then promptly shuttled into the nucleus for recombination. Peripheral application of ta...