Here, we show that closed-loop, SWR triggered neuromodulation of the medial forebrain bundle (MFB) can enhance fear extinction consolidation in male rats. The modified fear memories became resistant to induced recall (i.e., ‘renewal’ and ‘reinstatement’) and did not reemerge spontaneously. ...
You might want to think about destroying your fear and getting over it, if you learn about a study of rats.(害怕尝试新事物?如果你了解了一项关于老鼠的研究,你可能会想要摧毁你的恐惧并克服它)”以及第二段中“Rats that prefer to surround themselves with familiar things are likely to die at an...
This pattern has been previously observed in rats with lesions of the orbitofrontal region of PFC, suggesting that this structure may be involved in the behavioural phenomena observed here. We speculate that chronic gut inflammation interferes with the ability of OFPC to discriminate contexts (e.g....
At present study, we tested the effects of exogenous melatonin (2.5 mg/kg) on the acquisition, expression and extinction of cued fear in rats. Results: Results showed that a single afternoon administration 30 min before conditioning has no effect on the acquisition of cued fear. Compared to ...
Data will be reviewed using the acoustic startle reflex in rats and humans based on our attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety are very similar, they also differ. Fear is a generally adaptive state of apprehension that begins rapidly and ...
In the laboratory (as with rats) fear typically refers to emotional responses learned with an aversive stimulus. Presentation of an unpleasant stimulus like an electric shock typically elicits a variety of behaviors that are used to infer a central state of fear (Figure 1). After several pairings...
Figure 12.Contextual fear conditioning in rats. Rats were placed in the fear conditioning chamber for two minutes, then a one second shock (1.5mA) was delivered to the floor grid. This protocol was repeated for a total of five shocks with two minutes between each shock. Following the fifth...
In the 1920s, in what is probably not one of psychology's finest moments, American psychologist John Watson taught an infant to fear white rats. "Little Albert" had no fear of the laboratory's test animals. He showed joy at the sight of the white rats especially and always reached out ...
Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol Bull 1993; 114: 80–99. Article CAS PubMed Google Scholar Rauhut AS, Thomas BL, Ayres JJ . Treatments that weaken Pavlovian conditioned fear and thwart its renewal in rats: implications for ...
Drugs that block this so-called synaptic plasticity impair the ability to reform once-fearful memories (extinction learning), when they are injected into a brain region called the infralimbic prefrontal cortex (ILC). The result: Rats continue freezing at high levels even after they are trained to...