have unraveled a long-lasting role for fear engrams in future pain perception. Prefrontal pain and fear representations become entangled following a fearful event. As subsequent painful experiences also reactivate the fear network, silencing the fear engram alone can alleviate both tonic pain and ...
To assess the functional meaning of this overlap, we next tagged the prefrontal engram of long-term fear memory with the optogenetic inhibitory opsin archeorhodopsin (ArchT; Fig.1d,eand Extended Data Fig.2a,b). The Dox ON/Dox OFF dynamics and dosage were technically optimized to yield specific...