总之，理解并正确使用这些指标，如p-value、adjusted p-value（q-value）和FDR，对于防止因多重检验导致的误导性结果至关重要。在进行大规模数据分析时，需要综合考虑这些指标，以确保科研结论的准确性和可靠性。
and 2) the Storey pFDR 'q-value' procedure. In practice, however, the term 'q-value' has come to mean 'FDR-adjusted p-value', rather than specifically the Storey pFDR qvalue. The two methods will, however, yield identical results when ...
The FDR is very different from a p-value, and as such a much higher FDR can be tolerated than with a p-value. In the example above a set of 100 predictions of which 70 are correct might be very useful, especially if there are thousands of genes on the array most of which are not...
terminology "q-value" for a quantity estimates his definition of FDR. He implemented q-value estimation procedures in an R package called qvalue. So, strictly speaking, the q-value and the FDR adjusted p-value are similar but not quite the same. However the terms q-value and FDR adjusted...
(imagine the projector wasn't working), the probability of seeing so much asa single voxel above statistical threshold should be 0.05. There is obviously an arbitrary elementto this, and it's open to debate how quickly research would progress if this standard were adjusted.At least one of ...
FDR筛选时就可以不用遵循0.05这个标准了。...我们可以设置FDR<0.05表示我们容许数据中存在至多5%假阳性率;FDR<0.1表示我们对假阳性率的容忍度至多是10%。...adjusted P-value, q value, fdr一般代表相同的含义,都是多重假设检验校正后的P-value,可能的区别就在于校正算法的不同。 3.6K30 比较微生物组中的...
那么我们怎么从p value 来估算FDR呢,人们设计了几种不同的估算模型。其中使用最多的是Benjamini and Hochberg方法,简称BH法。虽然这个估算公式并不够完美,但是也能解决大部分的问题,主要还是简单好用! FDR的计算方法 除了可以使用excel的BH计算方法外,对于较大的数据,我们推荐使用R命令p.adjust。 p.adjust(p, met...
数据结果展示如下图所示(两分组)众多参数中,重点看三个。p-value或q-value没有做生物学重复请跳过这一步。p-value或q-value是统计学检验变量,代表差异 Volcano plot | 别再问我这为什么是火山图 FDR值是0-1之间,数值越小越是统计显著,也越是我们关注的。-Log 10 (adjustedP-value)转换后正好是反了多来,...
Want to share your content on R-bloggers? click here if you have a blog, or here if you don't. ShareTweet In this tutorial, we will show you how to apply the Benjamini-Hochberg procedure in order to calculate the False Discovery Rate (FDR) and the P-Value Adjusted. The Benjam...
terminology "q-value" for a quantity estimates his definition of FDR. He implemented q-value estimation procedures in an R package called qvalue.So, strictly speaking, the q-value and the FDR adjusted p-value are similar but not quite the same. However the terms ...