The US FDA is requiring manufacturers of conventional antipsychotics to add Boxed Warnings about the increased risk of death in elderly patients treated for dementia-related psychosis. 1 , 2 The FDA says that two observational epidemiological studies investigating the risk of death in elderly patients...
Like other antipsychotics, the drug carries a "boxed warning," FDA's most serious type of warning, informing prescribers of increased risk of death. And in the three pre-approval trials, the FDA concluded that the death rate was four times higher in those given brexpiprazole compared to those...
withotherantipsychotics.Whileimmediatediscontinuationofthepreviousantipsychotic treatmentmaybeacceptableforsomepatientswithschizophrenia,moregradual discontinuationmaybemostappropriateforothers.Inallcases,theperiodofoverlapping antipsychoticadministrationshouldbeminimized. 2.2BipolarIDisorder AcuteTreatmentofManicandMixedEpisodes Adu...
盐酸鲁拉西酮的说明书(FDA).pdf,LATUDA® (lurasidone HCl) Tablets • Hyperprolactinemia: Prolactin elevations may occur (5.6). • Leukopenia, Neutropenia, and Agranulocytosis have been reported with antipsychotics. Patients with a pre-existing low
(5.6) Leukopenia, Neutropenia, and Agranulocytosis: Has been reported with antipsychotics, including ZYPREXA. Patients with a history of a clinically significant low white blood cell count (WBC) or drug induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently ...
reported with antipsychotics. Patients with a pre-existing low white blood cell count (WBC) or a history of leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and SAPHRIS ...
Aminophylline/theophylline;Atypicalantipsychotics(e.g.,clozapine, olanzapine,risperidone,ziprasidone);Bupropion;ClassIAandIII antiarrhythmics(e.g.,amiodarone,bretylium,disopyramide,ibutilide, procainamide,quinidine,sotalol);Dolasetron;Droperidol; Gatafloxacin/moxifloxacin;Insulin;Lithium;Macrolideantibiotics(e.g., ...
Metabolic Changes, including hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. Hyperglycemia, in some cases extreme and associated with ketoacidosis, hyperosmolar coma or death, has been reported in patients treated with antipsychotics. Measur...
Antipsychotics: lurasidone, pimozide Benign prostatic hyperplasia agents: silodosin Cardiovascular agents: eplerenone, ivabradine Ergot derivatives: dihydroergotamine, ergotamine, methylergonovine HMG-CoA reductase inhibitors: lovastatin, simvastatin (these drugs can be temporarily discontinued to allow PAXL...
There is a pregnancy exposure registry for women who are exposed to REXULTI during pregnancy. If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by ...