The majority of drugs target ion channels or G-protein-coupled receptors (GPCRs) but the mechanistic basis for many NMEs remains unclear or controversial. These trends could suggest future opportunities for success in a crucial field with considerable unmet needs.Michael...
Small-moleculekinaseinhibitors:ananalysisofFDA-approveddrugs.DrugDiscovToday.2016Jan;21(1):5-105. FDA-approvedsmall-moleculekinaseinhibitors.TrendsinPharmacologicalSciences2015,36,422-4396. /Drugs/default.htm7. /scripts/cder/daf/index.cfm8. 部分药物信息查询自药渡网-药物数据...
的一篇药物综述文章《Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021》,介绍1991-2021年FDA批准的17 种治疗胃肠道癌症的新药。 背景 胃肠道癌症包括食管癌、胃癌...
4. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discov Today. 2016Jan;21(1):5-10 5. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences 2015,36,422-439 6. http://www.fda.gov/Drugs/default.htm 7. http://www.accessdata.fda.gov/...
4. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discov Today. 2016Jan;21(1):5-10 5. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences 2015,36,422-439 6. http://www.fda.gov/Drugs/default.htm 7. http://www.accessdata.fda.gov/...
4. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discov Today. 2016Jan;21(1):5-10 5. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences 2015,36,422-439 6. http://www.fda.gov/Drugs/default.htm 7. http://www.accessdata.fda.gov/...
Fig 2. Targets of FDA-approved small-molecule cancer drugs organized by approval date 图2中,我们根据FDA批准上市的时间为序,整理了小分子抗肿瘤药物所对应的靶点分类。在1982年之前获得批准的药物中,有超过31%其作用机制为诱导产生...
Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021 Alex Avdeef Manfred Kansy Journal of Solution Chemistry (2022) Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor...
Gmax is a clinical stage biopharmaceutical company established in 2010 and headquartered inHangzhou, China. It's a global company focusing on R&D, production and commercialization of antibody drugs targeting GPCRs. Gmax mainly...
Method of Treating and/or Preventing Inflammatory Diseases, including many Autoimmune and Neurological diseases, using drugs to modulate the VDR, and/or PPAR, and/or GCR and/or CB1 nuclear and GPCR receptors; in conjunction with antibiot... sufficiently small to stabilize the ARB level between 20...