的一篇药物综述文章《Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021》,介绍1991-2021年FDA批准的17 种治疗胃肠道癌症的新药。 背景 胃肠道癌症包括食管癌、胃癌...
Small-moleculekinaseinhibitors:ananalysisofFDA-approveddrugs.DrugDiscovToday.2016Jan;21(1):5-105. FDA-approvedsmall-moleculekinaseinhibitors.TrendsinPharmacologicalSciences2015,36,422-4396. /Drugs/default.htm7. /scripts/cder/daf/index.cfm8. 部分药物信息查询自药渡网-药物数据...
为便于说明学术性高通量筛选中心在药物发现中的作用,我们在www.cancer.gov中选取了FDA批准的121种小分子抗肿瘤药物作为分析对象,如图2所示。 Fig 2. Targets of FDA-approved small-molecule cancer drugs organized by approval date 图2...
6.Igalmi的处方信息见https://igalmihcp.com/igalmi-pi.pdf 7.https://www.drugs.com/history/igalmi.html#:~:text=FDA%20Approved%3A%20No%20Brand%20name%3A%20BXCL501%20Generic%20name%3A,dexmedetomidine%20Company%3A%20BioXcel%20Therapeutics%2C%20Inc.%20Treatment%20for%3A%20Agitation --- ...
The majority of drugs target ion channels or G-protein-coupled receptors (GPCRs) but the mechanistic basis for many NMEs remains unclear or controversial. These trends could suggest future opportunities for success in a crucial field with considerable unmet needs.Michael...
We screened our 23 validated candidates from Huh7.5 cells in Calu-3 cells and found only 9 drugs showed favorable activity, including 3 FDA-approved drugs: cyclosporine, dacomitinib, and salinomycin. In additional studies, we found that cyclosporine analogs that target Cyclophilin A were active ...
There is great interest in drugs that are capable of modulating multiple aging pathways, thereby delaying the onset and progression of aging. Effective str
4. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discov Today. 2016Jan;21(1):5-10 5. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences 2015,36,422-439 6. http://www.fda.gov/Drugs/default.htm 7. http://www.accessdata.fda.gov/...
FDA-approved therapeutic drugs for lung cancers.aDistribution of therapeutic drugs for lung cancers during the past 31 years (adapted from [126]).bMicrotubule inhibitor.cEGFR inhibitors and EGFR-directed mAb.dEGFR- and MET-bispecific antibody and EGFR inhibitor for NSCLC withEGFRex20insmutations.e...
SARS-CoV-2 A1pp domain Macro domain Nucleoside analogues FDA approved Drugs In silico 1. Introduction In December 2019, SARS-CoV-2, a novel coronavirus emerged in China, thereafter infecting more than seventy million individuals worldwide. Discovery of novel targeted drug(s) is needed and has ...