CDK Inhibitors and FDA: Approved and Orphandoi:10.3390/cancers16081555ORPHAN drugsHEMATOLOGIC malignanciesBREAST tumorsUNITED States. Food & Drug AdministrationDRUG approvalMETASTASISMOLECULAR structureCYCLIN-dependent kinasesGENOMESCHEMICAL inhibitorsCicenas, Jonas...
参考文献: [1]Wu,Q.,Qian,W.,Sun,X.et al.Small-molecule inhibitors,immune checkpoint inhibitors,and more:FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.J Hematol Oncol 15,143(2022).https://doi.org/10.1186/s13045-022...
参考文献: [1] Small-molecule inhibitors, immunecheckpointinhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.Journal of Hematology & Oncology2022.
Table 8. Properties of FDA-approved small molecule protein kinases inhibitors. DrugTarget, kinase familyaKi nMbpKiLipEcN * dLEeDosefSolgnRotBhnRnginArjnBnzkQEDl Abemaciclib CDK4, S/T 0.6 9.22 4.28 37 0.351 400 * 15.9 7 5 4 0 0.38 Abrocitinib JAK1, NRY 5.1 8.29 7.04 22 0.531 10...
2022年10月8日,杭州医学院的姜少杰等人,在知名肿瘤学期刊Journal of Hematology & Oncology发表了题为“Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021...
Bedaquiline, an FDA-approved drug, effectively inhibited mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the mitochondrial ATP-synthase. Full size image More importantly, ATP depletion induced by Bedaquiline also inhibited the growth of MDA-MB-231 ...
20CB2CMS20102011201220132014图3SmallmolecularkinaseinhibitorsapprovedbyFDAin2001-2016在获批的31中小分子激酶抑制剂类药物中(图3),绝大多数为酪氨酸激酶抑制剂,还有些届丁丝氨酸/氨酸激酶抑制剂,只有2014年七月获批的Idelalisib届于脂激酶类抑制剂。根据靶点蛋白与药物届性的不同,分类整理如下:FDA批准的可逆NRTK 7...
图3 Small molecular kinase inhibitors approved by FDA in 2001-2016 在获批的31中小分子激酶抑制剂类药物中(图3),绝大多数为酪氨酸激酶抑制剂,还有些属于丝氨酸/苏氨酸激酶抑制剂,只有2014年七月获批的Idelalisib属于脂激酶类抑制剂。根据靶点蛋白及药物属性的不同,分类整理如下: 1. FDA批准的可逆NRTK(非受体...
Basel, September 17, 2024 –Novartis today announced that the US Food and Drug Administration (FDA) has approved Kisqali® (ribociclib) in combination with an aromatase inhibitor (AI) for the adjuvant treatment of people with hormone ...
图3 Small molecular kinase inhibitors approved by FDA in 2001-2016 在获批的 31 中小分子激酶抑制剂类药物中 (图 3) ,绝大多数为酪氨酸激酶抑制 剂,还有些属于丝氨酸 / 苏氨酸激酶抑制剂,只有 2014 年七月获批的 Idelalisib 属于脂激酶类抑制剂。根据靶点蛋白及药物属性的不同,分类整理如 下: 1...